Ascidians and the plasticity of the chordate developmental program.
Ascidians and the plasticity of the chordate developmental program.
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DOI：
10.1016/j.cub.2008.05.039
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发表时间：
2008-07-22
期刊：
影响因子：
9.2
通讯作者：
Nishida, Hiroki
中科院分区：
文献类型：
--
作者：
Lemaire, Patrick;Smith, William C.;Nishida, Hiroki
关于产生第一批脊椎动物的古代脊索动物，人们知之甚少，但当时存在的其他无脊椎脊索动物的后代仍然在海洋中繁衍生息。这些无脊椎动物包括头脊索动物和被囊动物，它们的幼虫与脊椎动物胚胎有共同的身体结构，有中央脊索和背神经索。被囊动物现在被认为是脊椎动物的姐妹群。然而，基于几种海鞘（一种分布广泛的被囊动物）的研究表明，它们发育的分子策略似乎与脊椎动物的分子策略存在很大差异。此外，大多数被囊动物的成虫体表是在幼虫后广泛的蜕变后形成的，与其他脊索动物的体表几乎没有相似之处。在这篇综述中，我们比较了海鞘和脊椎动物的发育策略，并认为这些策略的差异揭示了脊索动物发育程序的惊人可塑性水平，并为确定脊索动物进化保守的核心调控机制提供了丰富的资源。此外，我们提出，对海鞘和脊椎动物基因调控网络结构的比较分析可能为脊索动物身体计划的起源提供重要的见解。
Little is known about the ancient chordates that gave rise to the first vertebrates, but the descendants of other invertebrate chordates extant at the time still flourish in the ocean. These invertebrates include the cephalochordates and tunicates, whose larvae share with vertebrate embryos a common body plan with a central notochord and a dorsal nerve cord. Tunicates are now thought to be the sister group of vertebrates. However, research based on several species of ascidians, a diverse and wide-spread class of tunicates, revealed that the molecular strategies underlying their development appear to diverge greatly from those found in vertebrates. Furthermore, the adult body plan of most tunicates, which arises following an extensive post-larval metamorphosis, shows little resemblance to the body plan of any other chordate. In this review, we compare the developmental strategies of ascidians and vertebrates and argue that the very divergence of these strategies reveals the surprising level of plasticity of the chordate developmental program and is a rich resource to identify core regulatory mechanisms that are evolutionarily conserved in chordates. Further, we propose that the comparative analysis of the architecture of ascidian and vertebrate gene regulatory networks may provide critical insight into the origin of the chordate body plan.
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影响因子：
3.3
作者：
Chang, P;Torres, J;King, ML
通讯作者：
King, ML
DOI：
10.1073/pnas.0600805103
发表时间：
2006-06-06
影响因子：
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作者：
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