Longitudinal assessment of airway caliber and responsiveness in workers exposed to chlorine
Longitudinal assessment of airway caliber and responsiveness in workers exposed to chlorine
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DOI：
10.1164/ajrccm.160.4.9811074
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发表时间：
1999-10-01
影响因子：
24.7
通讯作者：
Malo, JL
中科院分区：
文献类型：
--
作者：
Gautrin, D;Leroyer, C;Malo, JL
本文对某金属厂239名工人进行了1992-1994年的纵向研究，以确定意外氯暴露与肺功能和气道反应性变化之间的关系。这些工人参加了1992年的一次横断面调查。在初始和后续调查中，记录了氯接触史（“吸入”）、向急救单位报告的意外氯吸入史（中毒事件）以及慢性症状;进行了肺量测定和醋甲胆碱挑战测试。随访时，观察到211名工人（88.3%）。在吸烟20包-年或以上的工人中，FEV 1的下降与随访期间发生的气体事件有关; FEV 1/FVC（%）的下降通过两次评估之间引起轻度症状的抽吸次数预测。19名工人的气道反应性增加（PC 20降低> 1.5倍），这与前2年向急救单位报告的事故有关（OR：5.9，95%CI：1.1 - 32.3）。这些研究结果表明：（1）对气道功能的影响与估计的轻度症状和气体事件的抽吸次数有关，主要发生在吸烟者中;（2）与气体事件相关的气道反应性可检测到增加。
This longitudinal study (1992-1994) was performed to determine the relation between accidental chlorine exposure and changes in lung function and airway responsiveness in 239 workers in a metal production plant. These workers had taken part in a cross-sectional survey in 1992. In both the initial and the follow-up surveys, history of exposure to chlorine ("puffs"), accidental chlorine inhalation reported to the first-aid unit (gassing incidents), and of chronic symptoms were documented; spirometry and methacholine challenge tests were performed. At follow-up, 211 workers (88.3%) were seen. In workers with 20 pack-years or more of cigarette smoking, the fall in FEV1 was associated with having had a gassing incident during the follow-up period; the fall in FEV1/FVC (%) was predicted by the number of puffs causing mild symptoms between the two assessments. An increase in airway responsiveness (PC20 decrease > 1.5-fold) was present in 19 workers; it was associated with accidents reported to the first-aid unit during the previous 2 yr (OR: 5.9, 95% CI: 1.1 to 32.3). These findings suggest: (1) an effect on airway function related to the estimated number of puffs with mild symptoms and gassing incidents, mostly among smokers; (2) a detectable increase in airway responsiveness associated with gassing incidents.