Molecular cloning of an isoform of Doc2 having two C2-like domains
Molecular cloning of an isoform of Doc2 having two C2-like domains
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DOI：
10.1006/bbrc.1995.2876
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发表时间：
1995-12-26
影响因子：
3.1
通讯作者：
Takai, Y
中科院分区：
文献类型：
--
作者：
Sakaguchi, G;Orita, S;Takai, Y
我们之前分离出一种新型蛋白质，具有两个已知与 Ca2+ 和磷脂相互作用的 C2 样结构域，并将其命名为 Doc2 (Double C2)。Doc2 主要在大脑中表达，与 Ca2+ 依赖性神经递质释放有关。我们在这里分离出了 Doc2 的同种型，并将原始的同种型命名为 Doc2 alpha，将新的同种型命名为 Doc2 beta。 Doc2 beta 还具有两个 C2 样结构域，并且在氨基酸水平上与 Doc2 alpha 61% 相同。 Doc2 α、Doc2 β mRNA 普遍表达。这些结果表明Doc2至少有两种亚型，并表明Doc2β参与各种类型细胞中Ca2+依赖性细胞内囊泡运输。 (C) 1995 学术出版社
We previously isolated a novel protein having two C2-like domains known to interact with Ca2+ and phospholipid, and named Doc2 (Double C2) Doc2 is predominantly expressed in brain and is implicated in Ca2+-dependent neurotransmitter release. We have isolated here an isoform of Doc2 and named the original one Doc2 alpha and the new one Doc2 beta. Doc2 beta also has two C2-like domains and is 61% identical to Doc2 alpha at the amino acid level. Doc2 alpha, the Doc2 beta mRNA is expressed ubiquitously. These results indicate that there are at least two isoforms of Doc2, and suggest that Doc2 beta is involved in Ca2+-dependent intracellular vesicle trafficking in various types of cells. (C) 1995 Academic Press, Inc.