What will my child's future hold? phenotypes of intellectual development in 2-8-year-olds with autism spectrum disorder.
What will my child's future hold? phenotypes of intellectual development in 2-8-year-olds with autism spectrum disorder.
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我孩子的未来会怎样？
DOI：
10.1002/aur.1884
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Amaral,DavidG
中科院分区：
文献类型：
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作者：
Solomon,Marjorie;Iosif,Ana-Maria;Reinhardt,VanessaP;Libero,LaurenE;Nordahl,ChristineW;Ozonoff,Sally;Rogers,SallyJ;Amaral,DavidG
我们在最近临床确定的队列中，基于从早期（2-3 ½岁）到中期（5-8岁）儿童的智力发展轨迹，检查了自闭症谱系障碍（ASD）的表型。参与者包括102名儿童（82名男性），最初诊断为ASD，来自自闭症表型组项目纵向样本。潜在班级成长分析用于识别不同的智商轨迹。分别使用单变量技术和重复测量回归模型评估组间基线和发育过程差异。四类模型最能代表数据。使用最高后验概率，参与者被分配到高挑战（25.5%），稳定低（17.6%），改变者（35.3%）和较小挑战（21.6%）组。高挑战组和稳定低组表现出持续的低智商，尽管高挑战组经历了下降，而稳定低组的分数保持不变。改变者显示智商提高> 2个标准差。较小挑战组的智商在两个时间点都在平均范围内，在T2时高出约1个标准差。总而言之，75%的参与者在2岁至8岁之间的智力和/或其他功能领域有了一些相对的改善。改变者组表现出最显著的智商变化，伴随着适应性沟通的改善和外化症状的减少。只有较小挑战组的ASD症状严重程度显着降低，到8岁时，其中14%不再符合ASD的ADOS-2标准。所有组均显示内化症状减少。干预史与组状态无关。自闭症研究2018，11：121-132。© 2017 International Society for Autism Research，Wiley Periodicals，Inc.Lay SummaryWe研究了自闭症谱系障碍儿童的智商在2岁至8岁之间的变化，并确定了四种模式。两组人的智商持续较低。其中一组的智商提高了30分以上，沟通能力提高，破坏性行为减少。最后一组在两个时间点的智商都在平均或更好的范围内，其中14%的人失去了诊断。超过一半的儿童在2岁至8岁之间经历了智力功能的改善，而约25%的儿童表现出下降。结果与干预史无关。
We examined phenotypes of autism spectrum disorder (ASD) based on trajectories of intellectual development from early (ages 2–3 ½) to middle (ages 5–8) childhood in a recent clinically ascertained cohort. Participants included 102 children (82 males) initially diagnosed with ASD from the Autism Phenome Project longitudinal sample. Latent class growth analysis was used to identify distinct IQ trajectories. Baseline and developmental course differences among groups were assessed using univariate techniques and repeated measures regression models, respectively. A four class model best represented the data. Using the highest posterior probability, participants were assigned to High Challenges (25.5%), Stable Low (17.6%), Changers (35.3%), and Lesser Challenges (21.6%) groups. The High Challenges and Stable Low groups exhibited persistently low IQ, although, the High Challenges group experienced declines while the Stable Low group's scores remained more constant. Changers showed IQ improvement of > 2 standard deviations. The Lesser Challenges group had IQs in the average range at both times that were about 1 standard deviation higher at T2. In summation, 75% of the participants experienced some relative improvements in intellectual and/or other areas of functioning between ages 2 and 8 years. The Changers group demonstrated the most significant IQ change that was accompanied by adaptive communication improvement and declining externalizing symptoms. Only the Lesser Challenges group showed a significant reduction in ASD symptom severity, such that by age 8, 14% of them no longer met ADOS‐2 criteria for ASD. All groups showed reductions in internalizing symptoms. Intervention history was not associated with group status.Autism Res2018, 11: 121–132. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryWe examined how the IQs of children with autism spectrum disorder change between ages 2 and 8, and identified four patterns. Two groups exhibited persistently lower IQs. One group showed IQ increases of greater than 30 points with improved communicate abilities and declining disruptive behaviors. The final group had IQs in the average or better range at both time points, and 14% of them lost their diagnoses. Over half of the children experienced improved intellectual functioning between ages 2 and 8, whereas about 25% showed declines. Findings were not associated with intervention history.