The effect of age and bone mineral density on the absolute, excess, and relative risk of fracture in postmenopausal women aged 50-99: results from the National Osteoporosis Risk Assessment (NORA)
The effect of age and bone mineral density on the absolute, excess, and relative risk of fracture in postmenopausal women aged 50-99: results from the National Osteoporosis Risk Assessment (NORA)
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DOI：
10.1007/s00198-005-0027-4
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发表时间：
2006-04-01
影响因子：
4
通讯作者：
Chen, YT
中科院分区：
文献类型：
--
作者：
Siris, ES;Brenneman, SK;Chen, YT
本研究评估了年龄和骨矿物质密度（BMD）对绝经后妇女外周BMD测试3年内髋部、腕部、前臂、脊柱和肋骨骨折的绝对、过量和相对风险的影响。数据来自170,083名年龄在50-99岁的妇女，在从美国各地的初级保健医生办公室招募后，参加了国家骨质疏松症风险评估（诺拉）。在基线时获得骨折的危险因素和足跟、前臂或手指的外周BMD T评分。在1年和3年随访时，通过问卷调查获得了自我报告的髋关节、脊柱、肋骨、腕关节和前臂新发骨折。在随访中，5312名妇女报告了5676例骨折（868例髋关节骨折，2420例腕/前臂骨折，1531例肋骨骨折，857例脊柱骨折）。所有骨折部位的绝对骨折风险均随年龄增长而增加。这种年龄效应在髋部骨折中最为明显--低BMD女性髋部骨折的发病率和超额风险每增加10岁至少增加2倍。各年龄组BMD每降低1 SD发生骨折的相对风险相似（p > 0.07）。低BMD女性（T评分
This study evaluates the effect of age and bone mineral density (BMD) on the absolute, excess, and relative risk for osteoporotic fractures at the hip, wrist, forearm, spine, and rib within 3 years of peripheral BMD testing in postmenopausal women over a wide range of postmenopausal ages.Data were obtained from 170,083 women, aged 50-99 years, enrolled in the National Osteoporosis Risk Assessment (NORA) following recruitment from their primary care physicians' offices across the United States. Risk factors for fracture and peripheral BMD T-scores at the heel, forearm, or finger were obtained at baseline. Self-reported new fractures at the hip, spine, rib, wrist, and forearm were obtained from questionnaires at 1- and 3-year follow-ups. Absolute, excess (attributable to low BMD), and unadjusted and adjusted relative risks of fracture were calculated.At follow-up, 5312 women reported 5676 fractures (868 hip, 2420 wrist/forearm, 1531 rib, and 857 spine). Absolute risk of fracture increased with age for all fracture sites. This age-effect was most evident for hip fracture - both the incidence and the excess risk of hip fracture for women with low BMD increased at least twofold for each decade increase in age. The relative risk for any fracture per 1 SD decrease in BMD was similar across age groups (p > 0.07). Women with low BMD (T-score