Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE-/- mice from the development of atherosclerosis
Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE-/- mice from the development of atherosclerosis
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DOI：
10.1016/j.carpath.2012.02.003
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发表时间：
2012-11-01
影响因子：
3.7
通讯作者：
Breit, Samuel N.
中科院分区：
文献类型：
--
作者：
Johnen, Heiko;Kuffner, Tamara;Breit, Samuel N.
目的：MIC-1/GDF 15是TGF-β超家族的成员，其被认为在应激反应、炎症、组织损伤和修复、能量稳态和恶性肿瘤中具有多效性作用。MIC-1/GDF 15是近年来发现的一种新的心血管事件发生和动脉粥样硬化疾病治疗结果的生物标志物。我们研究的目的是确定MIC-1是否在动脉粥样硬化的发展过程中也直接发挥促动脉粥样硬化或抗动脉粥样硬化的特性。方法和结果：我们研究了在ApoE（-/-）小鼠动脉粥样硬化模型中巨噬细胞中MIC-1转基因过表达的影响。高脂饮食6个月后，MIC-1/GDF 15转基因ApoE（-/-）小鼠的动脉粥样硬化病变较小;然而，未检测到病变组成、促炎或抗炎细胞因子产生或脂质或细胞因子血清水平的差异。结论：我们的研究结果表明，MIC-1对疾病过程具有整体保护作用，但需要进一步研究以确定其作用机制。(C)2012 Elsevier Inc. All rights reserved.
Aim: MIC-1/GDF15 is a member of the TGF-b superfamily, which is thought to have pleiotropic roles in stress responses, inflammation, tissue injury and repair, energy homeostasis, and malignancy. MIC-1/GDF15 was recently identified as a new biomarker for the development of cardiovascular events and the outcome of atherosclerotic disease therapy. The aim of our study was to determine if MIC-1 also directly exerts pro- or antiatherogenic properties during the development of atherosclerosis. Methods and results: We investigated the effect of transgenic overexpression of MIC-I in macrophages in the ApoE(-/-) mouse model of atherosclerosis. After 6 months of high-fat diet, MIC-1/GDF 15 transgenic ApoE(-/-) mice had smaller atherosclerotic lesions; however, no differences in lesion composition, pro- or anti-inflammatory cytokine production, or serum levels of lipids or cytokines were detected. Conclusions: Our results suggest that MIC-1 has an overall protective effect on the disease process, but further studies will be required to define its mechanism of action. (C) 2012 Elsevier Inc. All rights reserved.