The effect of beta-blockade on heart rate recovery following exercise stress echocardiography.
The effect of beta-blockade on heart rate recovery following exercise stress echocardiography.
复制标题
DOI：
10.1111/j.1520-037x.2007.07310.x
复制
发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Baker, Larry
中科院分区：
文献类型：
--
作者：
Karnik, Rahool S;Lewis, William;Baker, Larry
本研究的目的是确定β受体阻滞剂（BB）对运动负荷试验后心率恢复（HRR）的影响。HRR是运动负荷试验后死亡率的预测因子，被认为是由于迷走神经张力的重建。在存在BB的情况下进行运动试验对迷走神经张力的重建没有影响，因此对HRR没有影响。一项已发表的研究与这种理解相矛盾。作者对加州大学戴维斯分校的跑步机数据库进行了回顾性分析，发现334例接受运动负荷超声心动图（ESE）的患者数据完整。将接受ESE但未接受BB的患者与接受BB的患者进行比较。在无应激诱发的超声心动图异常（ESE结果阴性）的患者中，使用BB不会影响HRR。在应激诱发的超声心动图异常（阳性ESE结果）患者中，与阴性ESE患者相比，HRR延迟。BB的使用改善了ESE阳性患者的HRR。在ESE结果阴性的患者中，BB不影响HRR，HRR可用于死亡率预测。在ESE结果阳性的患者中，存在BB时HRR得到改善。
The purpose of this study was to determine the effects of beta-blockers (BBs) on heart rate recovery (HRR) following exercise stress testing. HRR is a predictor of mortality following exercise stress testing and is thought to be due to reinstitution of vagal tone. Exercise testing in the presence of BBs should have no effect on reinstitution of vagal tone and therefore no effect on HRR. One published study contradicts this understanding. The authors performed a retrospective analysis of the University of California, Davis, treadmill database and found 334 patients who underwent exercise stress echocardiography (ESE) with complete data. Patients undergoing ESE without a BB were compared with patients who were receiving a BB. HRR was not affected by BB use in patients without stress-induced echocardiographic abnormalities (negative ESE result). In patients with stress-induced echocardiographic abnormalities (positive ESE result), HRR was delayed compared with patients with negative ESE. BB use improved HRR in patients with positive ESE. BBs do not affect HRR in patients with a negative ESE result, and HRR can be used for mortality prediction. In patients with a positive ESE result, HRR is improved in the presence of a BB.