Listeria monocytogenes: cell biology of invasion and intracellular growth.
Listeria monocytogenes: cell biology of invasion and intracellular growth.
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DOI：
10.1128/microbiolspec.gpp3-0013-2018
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发表时间：
2018-11
影响因子：
3.7
通讯作者：
J. Pizarro-Cerdá;P. Cossart
中科院分区：
文献类型：
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作者：
J. Pizarro-Cerdá;P. Cossart
摘要革兰氏阳性病原体单核细胞增生李斯特菌能够通过引发质膜重塑，导致细菌吞噬，从而促进其进入多种哺乳动物宿主细胞。细胞侵入后，L.单核细胞增多症破坏其内化泡并易位至细胞质，在细胞质中发生细菌复制。随后，L。单核细胞增多症使用基于肌动蛋白的运动系统，其允许细菌细胞质运动和细胞间传播。L.因此，单核细胞增多症在不同的感染步骤破坏宿主细胞受体、细胞器和细胞骨架，操纵多种细胞功能，包括离子转运、膜运输、翻译后修饰、磷酸肌醇产生、先天免疫应答以及基因表达和DNA稳定性。
ABSTRACT The Gram-positive pathogen Listeria monocytogenes is able to promote its entry into a diverse range of mammalian host cells by triggering plasma membrane remodeling, leading to bacterial engulfment. Upon cell invasion, L. monocytogenes disrupts its internalization vacuole and translocates to the cytoplasm, where bacterial replication takes place. Subsequently, L. monocytogenes uses an actin-based motility system that allows bacterial cytoplasmic movement and cell-to-cell spread. L. monocytogenes therefore subverts host cell receptors, organelles and the cytoskeleton at different infection steps, manipulating diverse cellular functions that include ion transport, membrane trafficking, post-translational modifications, phosphoinositide production, innate immune responses as well as gene expression and DNA stability.