Contribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeastern Thailand
Contribution of epigenetic risk factors but not p53 codon 72 polymorphism to the development of cervical cancer in Northeastern Thailand
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DOI：
10.1016/j.canlet.2004.03.039
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发表时间：
2004-07-16
期刊：
影响因子：
9.7
通讯作者：
Ishida, T
中科院分区：
文献类型：
--
作者：
Settheetham-Ishida, W;Singto, Y;Ishida, T
在泰国东北部，研究了宫颈癌与危险因素之间的关系。收集宫颈鳞状细胞癌(SCCA)患者90例，年龄匹配的健康对照组100例。采用聚合酶链式反应-限制性片段长度多态技术对P53基因第72密码子的等位基因--脯氨酸和精氨酸进行分析。SCCA组的等位基因和基因型分布与对照组比较差异无统计学意义(P>；0.05)。在性伴数量(P<；0.003)、首次性交年龄(P<；0.03)和生育次数(P<；0.006)方面有显著差异。在调整了年龄和P53基因后，性伴人数仍有显著差异(P=0.017)。伴侣吸烟增加了发生SCCA的风险。当伴侣现在(3.31；P<；0.003)和过去(3.36；P<；0.003)都有吸烟史时，观察到更高的优势比。P53基因多态本身可能不是泰国东北部宫颈癌的风险因素。在本地区宫颈癌的预防工作中，应注意其他危险因素的存在，如性行为、吸烟习惯等。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
Relationships between cervical cancer and risk factors were investigated in Northeastern Thailand. Cases (n = 90) with squamous cell cervical cancer (SCCA) and age matched healthy controls (n = 100) were recruited. The p53 codon 72 polymorphism, proline and arginine allele, was studied by the polymerase chain reaction-restriction fragment length polymorphism. There was no significant difference in the allele and the genotype distribution between the SCCA and the control groups (P > 0.05). Significant difference was observed in the number of sexual partners (P < 0.003), age at the first sexual intercourse (P < 0.03) and number of parities (P < 0.006). After adjusted by age and p53 genotype, significant difference was still observed in the number of sexual partners (P = 0.017). The partners' smoking increased the risk to develop SCCA. Increased odds ratios were observed when the partner had smoking history both at present (3.31; P < 0.003) and in the past (3.36; P < 0.003). The p53 polymorphism itself may not be a risk factor for cervical cancer in Northeastern Thailand. Much attention should be paid to the presence of other risk factors such as sexual behaviors and smoking habits in the prevention of cervical cancer in this region. (C) 2004 Elsevier Ireland Ltd. All rights reserved.