Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France
Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France
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DOI：
10.1177/1352458507077938
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发表时间：
2007-09-01
影响因子：
5.8
通讯作者：
Guillemin, F.
中科院分区：
文献类型：
--
作者：
Debouverie, M.;Pittion-Vouyovitch, S.;Guillemin, F.
本研究的目的是描述多发性硬化症（MS）的患病率和发病率在洛林，法国，其长期趋势，从1990年至2002年。病例来源于洛林地区MS医护人员的区域网络，包括根据Poser标准确诊或疑似MS的所有病例。2004年12月31日，我们确定了2718例MS患者。患病率为1201100000（95%置信区间[Cl]：119-121）。1990年至2002年，年龄和性别调整的平均年发病率为5.5/10万（95% CI：4.4-6.6）。在同一时期，妇女的总发病率显著增加，但男子没有。MS发病时的平均年龄、发病后5年的残疾评分、前5年的复发次数以及首次发作伴后遗症或多症状性症状的比例在研究期间的每个年度队列之间没有显著差异。我们在研究中发现MS的患病率和发病率高于法国以前的研究。1990年至2002年MS发病率的增加，主要发生在女性，与更好地确定轻度残疾患者无关。
This study aims to describe the prevalence and incidence rates of multiple sclerosis (MS) in Lorraine, France, and its secular trend from 1990 to 2002. Cases were sourced from the regional network of MS healthcare workers in the Lorraine region and include all cases with definite or probable MS according to Poser's criteria. We identified 2718 patients with MS on 31 December 2004. The prevalence rate was 1201100 000 (95% confidence interval [Cl]: 119-121). Between 1990 and 2002, the average age- and sex-adjusted annual incidence rate was 5.5/100 000 (95% Cl: 4.4-6.6). During this same period, there was a significant increase in overall incidence in women but not in men. The mean age at MS onset, disability score five years after onset, number of relapses during the first five years, and proportion of first attack with sequelae or polysymptornatic symptoms were not significantly different between each annual cohort during the study period. The prevalence and incidence rates of MS we found in our study were higher than in previous studies in France. The increase in incidence of MS between 1990 and 2002, mostly in women, was not related to better ascertainment of patients with mild disability.