AMBULATORY BLOOD PRESSURE PATTERNS IN PATIENTS WITH RETINAL VEIN OCCLUSION.
AMBULATORY BLOOD PRESSURE PATTERNS IN PATIENTS WITH RETINAL VEIN OCCLUSION.
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DOI：
10.1097/iae.0000000000001071
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
Chavala SH
中科院分区：
文献类型：
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作者：
Rao VN;Ulrich JN;Viera AJ;Parlin A;Fekrat S;Chavala SH
睡眠期间血压 (BP) 未能下降（非下降模式）与心血管疾病 (CVD) 和中风有关。先前尚未研究与中风相关的视网膜静脉阻塞（RVO）患者中非浸渍性和隐匿性高血压的患病率和程度。我们测量了 22 名 RVO 患者和 20 名没有已知眼部疾病且年龄和性别相匹配的对照参与者的诊所血压和 24 小时动态血压。平均血压下降（定义为平均清醒和睡眠收缩压与平均清醒收缩压之差的比率）以及组间的隐匿性高血压和夜间高血压进行了比较。 RVO 患者的平均 24 小时动态血压为 144/79 mmHg，对照组为 136/77 mmHg。 RVO 患者的非浸渍模式患病率几乎高出两倍（80.8% (95% CI 52.8, 94.1) vs. 50.4% (95% CI 26.1, 74.5)；p=0.008）。 RVO 患者的平均睡眠收缩压下降为 6.1%，而对照组为 11.9%（p=0.004）。与对照组相比，更多的 RVO 患者因动态血压而患有隐性高血压（71% 对 50%），但这种差异并不具有统计学意义。我们的数据表明 RVO 与非杓型血压模式之间存在关联。动态血压监测可能有助于通过识别那些可能受益于更积极的血压控制的患者来评估 RVO 患者。
Failure of blood pressure (BP) to dip during sleep (non-dipper pattern) is associated with cardiovascular disease (CVD) and stroke. The prevalence and degree of non-dipping and masked hypertension in patients with retinal vein occlusion (RVO), which is associated with stroke, has not been previously examined. We measured clinic and 24-hour ambulatory BPs in 22 patients with RVO and 20 control participants without known eye disease matched by age and sex. Mean BP dipping, defined as the ratio of difference in mean awake and sleep systolic BPs to mean awake systolic BP, and masked and nocturnal hypertension were compared between groups. Mean 24-hour ambulatory BP was 144/79 mmHg among those with RVO and 136/77 mmHg among controls. Patients with RVO had an almost two-fold higher prevalence of non-dipping pattern (80.8% (95% CI 52.8, 94.1) vs. 50.4% (95% CI 26.1, 74.5);p=0.008). Average sleep systolic BP dip in RVO patients was 6.1% vs. 11.9% in controls (p=0.004). More RVO patients had masked hypertension by ambulatory BPs than controls (71% vs. 50%), but this difference was not statistically significant. Our data suggest an association between RVO and non-dipper BP pattern. Ambulatory BP monitoring may be useful in the evaluation of patients with RVO by identifying those who may benefit from more aggressive BP control.