The role of human papillomavirus in head and neck squamous cell carcinoma: A case control study on a southern Chinese population
The role of human papillomavirus in head and neck squamous cell carcinoma: A case control study on a southern Chinese population
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DOI：
10.1002/jmv.24405
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发表时间：
2016-05-01
影响因子：
12.7
通讯作者：
Chan, Paul K. S.
中科院分区：
文献类型：
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作者：
Chor, Josette S. Y.;Vlantis, Alexander C.;Chan, Paul K. S.
HPV在部分头颈部鳞状细胞癌（HNSCC）的发展中起作用，但其在中国南方人群中的作用信息有限。进行了多中心病例对照研究。检测HPV型别、病毒整合、E6/7 mRNA表达情况及TP53突变情况。共纳入228例HNSCC，其中口腔SCC 137例（60.1%），口咽SCC 34例（14.9%），喉部SCC 31例（13.6%），下咽SCC 21例（9.2%），唇部和鼻窦SCC 5例（2.2%）。7.5%（17/228）的HNSCC中存在高危HPV感染，但只有一小部分样本存在病毒整合（5.3%,12/228）或e6 / 7mrna表达（4.4%,10/228）。具有致癌表型（整合和E6/7 mRNA表达）的HPV感染在口咽SCC中比对照组更常见(9/34,26.5% vs. 0/42, 0.0%， P
HPV plays a role in the development of a portion of head and neck squamous cell carcinoma (HNSCC), but only limited information on its role in southern Chinese population is available. A multicenter case-control study was conducted. HPV type, viral integration, E6/7 mRNA expression status, and TP53 mutation were determined. A total of 228 HNSCC were recruited including 137 (60.1%) oral SCC, 34 (14.9%) oropharyngeal SCC, 31 (13.6%) laryngeal SCC, 21 (9.2%) hypopharyngeal SCC, and 5 (2.2%) lip and paranasal sinus SCC. High-risk HPV infection was found in 7.5% (17/228) of HNSCC, but only a small proportion of samples had evidence of viral integration (5.3%, 12/228) or E6/7 mRNA expression (4.4%, 10/228). HPV infection with oncogenic phenotype (integration and E6/7 mRNA expression) was significantly more common in oropharyngeal SCC than controls (9/34, 26.5% vs. 0/42, 0.0%, P