Innate immune sensing of coronavirus and viral evasion strategies.
Innate immune sensing of coronavirus and viral evasion strategies.
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DOI：
10.1038/s12276-021-00602-1
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发表时间：
2021-05
影响因子：
12.8
通讯作者：
Yoo JS
中科院分区：
文献类型：
--
作者：
Kasuga Y;Zhu B;Jang KJ;Yoo JS
天然免疫系统是抵御病原体和有害物质的宿主防御计划的第一道防线。抗病毒先天免疫反应可由感知病毒成分的多个细胞受体触发。被激活的先天免疫系统产生干扰素(IFN)和细胞因子，执行抗病毒功能，以消除入侵的病毒。冠状病毒是单链、阳性的RNA病毒，有广泛的动物宿主。冠状病毒已经进化出多种方法来逃避宿主的抗病毒免疫反应。冠状病毒成功的免疫逃逸可能使病毒适应多种宿主生物。冠状病毒从人畜共患宿主向人类传播已导致严重疾病，如严重急性呼吸综合征(SARS)、中东呼吸综合征(MERS)和2019年冠状病毒病(新冠肺炎)，导致全球卫生和经济危机。在这篇综述中，我们总结了关于冠状病毒入侵的宿主感知和天然免疫反应的机制，以及冠状病毒的宿主免疫逃避策略的最新知识。了解先天性免疫系统如何感知冠状病毒，以及冠状病毒如何逃脱检测，可以为应对感染提供新的方法。冠状病毒，包括SARS-CoV-2，不断进化以操纵、阻止和逃避宿主免疫反应。由日本札幌北海道大学的Ji-Seung Yoo领导的一个研究小组回顾了对冠状病毒的先天免疫反应和病毒逃避策略的理解。两个主要的受体家族在感染时识别RNA病毒，但它们如何应对SARS-CoV-2尚不清楚。受体TLR7在感知冠状病毒感染方面发挥着关键作用，TLR7基因的突变与年轻新冠肺炎患者的严重疾病和死亡率有关。激活宿主TLR通路可能被证明是一种有用的治疗方法。需要进一步深入研究特定的冠状病毒蛋白和抑制宿主免疫的病毒机制。
The innate immune system is the first line of the host defense program against pathogens and harmful substances. Antiviral innate immune responses can be triggered by multiple cellular receptors sensing viral components. The activated innate immune system produces interferons (IFNs) and cytokines that perform antiviral functions to eliminate invading viruses. Coronaviruses are single-stranded, positive-sense RNA viruses that have a broad range of animal hosts. Coronaviruses have evolved multiple means to evade host antiviral immune responses. Successful immune evasion by coronaviruses may enable the viruses to adapt to multiple species of host organisms. Coronavirus transmission from zoonotic hosts to humans has caused serious illnesses, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease-2019 (COVID-19), resulting in global health and economic crises. In this review, we summarize the current knowledge of the mechanisms underlying host sensing of and innate immune responses against coronavirus invasion, as well as host immune evasion strategies of coronaviruses. Understanding how the innate immune system senses coronaviruses and how coronaviruses can escape detection could provide novel approaches to tackle infections. Coronaviruses, including SARS-CoV-2, constantly evolve to manipulate, obstruct and evade host immune responses. A team led by Ji-Seung Yoo, Hokkaido University, Sapporo, Japan, reviewed understanding of innate immune responses to coronaviruses and viral evasion strategies. Two major receptor families recognise RNA viruses upon infection, but how they respond to SARS-CoV-2 is unclear. One receptor, TLR7, plays a critical role in sensing coronavirus infections, and mutations in the TLR7 gene are associated with severe illness and mortality in young Covid-19 patients. Activating host TLR pathways may prove a useful therapeutic approach. Further in-depth investigations are needed into specific coronavirus proteins and viral mechanisms that suppress host immunity.
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DOI：
10.1126/science.abd3072
发表时间：
2020-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Daly JL;Simonetti B;Klein K;Chen KE;Williamson MK;Antón-Plágaro C;Shoemark DK;Simón-Gracia L;Bauer M;Hollandi R;Greber UF;Horvath P;Sessions RB;Helenius A;Hiscox JA;Teesalu T;Matthews DA;Davidson AD;Collins BM;Cullen PJ;Yamauchi Y
通讯作者：
Yamauchi Y
DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
30.3
作者：
Amini-Bavil-Olyaee S;Choi YJ;Lee JH;Shi M;Huang IC;Farzan M;Jung JU
通讯作者：
Jung JU
冠状病毒类木瓜蛋白酶的去泛素化和干扰素拮抗活性
影响因子：
5.4
作者：
Clementz, Mark A.;Chen, Zhongbin;Baker, Susan C.
通讯作者：
Baker, Susan C.
影响因子：
6.4
作者：
Angelini MM;Akhlaghpour M;Neuman BW;Buchmeier MJ
通讯作者：
Buchmeier MJ