Effects of kappa opioid receptors on conditioned place aversion and social interaction in males and females.
Effects of kappa opioid receptors on conditioned place aversion and social interaction in males and females.
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DOI：
10.1016/j.bbr.2014.01.003
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发表时间：
2014-04-01
影响因子：
2.7
通讯作者：
Trainor, Brian C.
中科院分区：
文献类型：
--
作者：
Robles, Cindee F.;McMackin, Marissa Z.;Campi, Katharine L.;Doig, Ian E.;Takahashi, Elizabeth Y.;Pride, Michael C.;Trainor, Brian C.
基于对雄性啮齿动物的研究，κ阿片受体（KOR）对动机行为的影响已得到充分证实，但对KOR在雌性动物中的影响知之甚少。我们研究了KOR激活对加州小鼠（Peromyscus californicus）条件性位置厌恶和社会互动的影响。在长期（地点厌恶）和短期（社会互动）效应中观察到重要差异。接受2.5 mg/kg剂量U 50，488给药的雌性动物（而非雄性动物）形成了位置厌恶，而接受10 mg/kg剂量给药的雄性动物（而非雌性动物）形成了位置厌恶。相反，不同剂量的U 50，488对雄性和雌性的社会交往行为的短期影响相似。急性注射10 mg/kg U 50，488（但不是较低剂量）减少了雄性和雌性的社会互动行为。U 50，488对磷酸化细胞外信号调节激酶（pERK）和p38 MAP激酶的作用具有细胞类型和区域特异性。较高剂量的U 50，488增加了雄性而不是雌性的终纹腹外侧床核中pERK神经元的数量，该核与雄性攻击行为有关。相比之下，用U 50，488处理的雄性和雌性在核壳中具有更多活化的p38细胞。出乎意料的是，表达活化的p38的细胞共表达Iba-1，一种广泛使用的小胶质细胞标记物。总之，我们发现强烈的性别差异的影响，U 50，488的位置厌恶，而急性影响U 50，488诱导相似的行为影响，男性和女性。
The effects of kappa opioid receptors (KOR) on motivated behavior are well established based on studies in male rodents, but relatively little is known about the effects of KOR in females. We examined the effects of KOR activation on conditioned place aversion and social interaction in the California mouse (Peromyscus californicus). Important differences were observed in long-term (place aversion) and short-term (social interaction) effects. Females but not males treated with a 2.5mg/kg dose of U50,488 formed a place aversion, whereas males but not females formed a place aversion at the 10 mg/kg dose. In contrast the short term effects of different doses of U50,488 on social interaction behavior were similar in males and females. Acute injection with 10 mg/kg of U50,488 (but not lower doses) reduced social interaction behavior in both males and females. The effects of U50,488 on phosphorylated extracellular signal regulated kinase (pERK) and p38 MAP kinase were cell type and region specific. Higher doses of U50,488 increased the number of pERK neurons in the ventrolateral bed nucleus of the stria terminals in males but not females, a nucleus implicated in male aggressive behavior. In contrast, both males and females treated with U50,488 had more activated p38 cells in the nucleus accumbens shell. Unexpectedly, cells expressing activated p38 co-expressed Iba-1, a widely used microglia marker. In summary we found strong sex differences in the effects of U50,488 on place aversion whereas the acute effects on U50,488 induced similar behavioral effects in males and females.
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影响因子：
12.4
作者：
Feng, X.;Wu, C-Y;Wei, L-N
通讯作者：
Wei, L-N
影响因子：
3.6
作者：
BECHARA, A;VANDERKOOY, D
通讯作者：
VANDERKOOY, D
重复的游泳应力诱导阿片类阿片类药物介导的细胞外信号调节激酶1/2的激活。
影响因子：
1.7
作者：
Bruchas MR;Xu M;Chavkin C
通讯作者：
Chavkin C
影响因子：
5
作者：
Bolanos, CA;Garmsen, GM;McDougall, SA
通讯作者：
McDougall, SA
影响因子：
3.4
作者：
BALSKUBIK, R;HERZ, A;SHIPPENBERG, TS
通讯作者：
SHIPPENBERG, TS