Auditory cortical detection and discrimination correlates with communicative significance
Auditory cortical detection and discrimination correlates with communicative significance
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DOI：
10.1371/journal.pbio.0050173
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发表时间：
2007-07-01
期刊：
影响因子：
9.8
通讯作者：
Schreiner, Christoph E.
中科院分区：
文献类型：
--
作者：
Liu, Robert C.;Schreiner, Christoph E.
可塑性研究表明，行为关联可以改变皮层对训练或条件感觉刺激的处理。然而，这是否发生在自然交流的背景下，刺激意义是通过社会互动获得的，还没有得到很好的研究，也许是因为对物种特异性发声的神经反应很难在系统框架内解释。孤立的小鼠幼崽和成年母鼠之间的超声波通信系统可以识别或不识别呼叫的重要性，这为探索这个问题提供了机会。我们采用基于信息的分析方法，从麻醉的母鼠和未接触幼崽的母鼠收集了多单位和单单位数据，以量化幼崽叫声的交流意义如何影响它们在听觉皮层的编码。与幼稚的雌性相比，雌性的皮层反应传达的幼犬呼叫检测和识别信息的时间和大小（以2毫秒的分辨率）显着改善，这很可能是由于呼叫频率编码的变化。这不是在老鼠发声曲目之外的非自然声音合奏的情况。结果表明，交流声音的时间编码的感觉皮层变化与发声的行为相关性相关，可能通过提高其信噪比来增强功能处理。
Plasticity studies suggest that behavioral relevance can change the cortical processing of trained or conditioned sensory stimuli. However, whether this occurs in the context of natural communication, where stimulus significance is acquired through social interaction, has not been well investigated, perhaps because neural responses to species-specific vocalizations can be difficult to interpret within a systematic framework. The ultrasonic communication system between isolated mouse pups and adult females that either do or do not recognize the calls' significance provides an opportunity to explore this issue. We applied an information-based analysis to multi-and single unit data collected from anesthetized mothers and pup-naive females to quantify how the communicative significance of pup calls affects their encoding in the auditory cortex. The timing and magnitude of information that cortical responses convey (at a 2-ms resolution) for pup call detection and discrimination was significantly improved in mothers compared to naive females, most likely because of changes in call frequency encoding. This was not the case for a non-natural sound ensemble outside the mouse vocalization repertoire. The results demonstrate that a sensory cortical change in the timing code for communication sounds is correlated with the vocalizations' behavioral relevance, potentially enhancing functional processing by improving its signal to noise ratio.