Associations of maternal and umbilical cord hormone concentrations with maternal, gestational and neonatal factors (United States)
Associations of maternal and umbilical cord hormone concentrations with maternal, gestational and neonatal factors (United States)
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DOI：
10.1023/a:1023934518975
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发表时间：
2003-05-01
影响因子：
2.3
通讯作者：
Hoover, RN
中科院分区：
文献类型：
--
作者：
Troisi, R;Potischman, N;Hoover, RN
目的：成人某些癌症的风险与几个怀孕因素有关，包括母亲年龄较大和出生体重。对于乳腺癌相关的癌症，这些影响被假设为通过子宫内较高的雌激素浓度介导。此外，妊娠激素水平的种族差异被认为是导致睾丸癌和前列腺癌风险的种族差异的原因。然而，与妊娠这些特征相关的激素水平的数据很少，特别是那些来自胎儿循环研究的数据。方法：测定86例正常单胎妊娠的母体和脐带血清中雌激素和雄激素的浓度。出生人数（重量，身长和头围）与母体雌三醇呈正相关（r = 0.25-0.36）和脐带DHEAS浓度（r = 0.24-0.41），但不与脐带血清中的雌激素。母亲年龄与母亲DHEAS、雄烯二酮和睾酮浓度呈负相关（r分别为-0.30、-0.25和-0.30），但与母亲或脐带循环中的雌激素无关。黑人母亲比白色母亲有更高的雄烯二酮和睾酮浓度，然而，脐带血清中的任何雄激素都没有种族差异。脐带睾酮浓度较高的男性胎儿的母亲，而母亲和脐带的雌三醇浓度较低，在这些pregnancy.Conclusions：这些数据表明激素浓度和妊娠因素与后代的癌症风险之间的关联，但是，所涉及的激素和它们的关联模式不同，无论是母亲或胎儿的循环采样。这项研究中胎儿循环中的激素浓度与流行病学研究中观察到的高出生体重婴儿中更高的雌激素浓度与乳腺癌风险呈正相关的假设不一致，或者与黑人男性子宫内环境中更高的睾酮暴露解释其随后更高的前列腺癌风险的假设不一致。
Objective: Risks of some cancers in adults have been associated with several pregnancy factors, including greater maternal age and birth weight. For hormone-related cancers, these effects are hypothesized to be mediated through higher in utero estrogen concentrations. In addition, racial differences in pregnancy hormone levels have been suggested as being responsible for differences in testicular and prostate cancer risk by race. How ever, data on hormonal levels related to these characteristics of pregnancy are sparse, particularly those from studies of the fetal circulation.Methods: Estrogen and androgen concentrations were measured in maternal and umbilical cord sera from 86 normal, singleton pregnancies.Results: Birth size measures (weight, length and head circumference) were positively correlated with maternal estriol (r = 0.25-0.36) and with cord DHEAS concentrations (r = 0.24-0.41), but not with estrogens in cord sera. Maternal age was inversely correlated with maternal DHEAS, androstenedione and testosterone concentrations (r = -0.30, -0.25 and -0.30, respectively), but uncorrelated with estrogens in either the maternal or cord circulation. Black mothers had higher androstenedione and testosterone concentrations than white mothers, however, there were no racial differences in any of the androgens in cord sera. Cord testosterone concentrations were higher in mothers of male fetuses, while both maternal and cord concentrations of estriol were lower in these pregnancies.Conclusions: These data demonstrate associations between hormone concentrations and pregnancy factors associated with offspring's cancer risk, however, the hormones involved and their patterns of association differ by whether the maternal or fetal circulation was sampled. Horm one concentrations in the fetal circulation in this study are not consistent with the hypothesis that greater estrogen concentrations in high birth weight babies mediate the positive association with breast cancer risk observed in epidemiologic studies, or with the hypothesis that higher testosterone exposure in the in utero environment of black males explains their higher subsequent prostate cancer risk.