Nitrogen-Doped Graphdiyne Quantum-dots as an Optical-Electrochemical Sensor for Sensitive Detection of Dopamine
Nitrogen-Doped Graphdiyne Quantum-dots as an Optical-Electrochemical Sensor for Sensitive Detection of Dopamine
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DOI：
10.1016/j.microc.2022.107521
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发表时间：
2022-04
影响因子：
4.8
通讯作者：
Q. Bai;H. Luo;Xuetao Yi;Shugao Shi;Lina Wang;Manhong Liu;Fanglin Du;Zhugen Yang;Ning Sui
中科院分区：
文献类型：
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作者：
Q. Bai;H. Luo;Xuetao Yi;Shugao Shi;Lina Wang;Manhong Liu;Fanglin Du;Zhugen Yang;Ning Sui
石墨炔量子点（GDQDs）由于其独特的电子、光学和电化学性能而受到越来越多的关注。然而，GDQDs的低电导率和量子产率限制了其应用。本文首次采用简单、友好的一步水热法合成了氮掺杂石墨烯点（N-GDQDs）。在319 nm激发波长下，N-GDQDs的最大发射波长为410 nm。掺杂N修饰了N- gdqds的表面缺陷，使其量子产率从14.6%提高到48.6%。此外，N的掺杂使N- gdqds具有较强的电子传递能力和良好的导电性。随后，将制备的N-GDQDs用于构建光学电化学纳米传感器，用于灵敏和选择性地检测多巴胺（DA）。DA通过在DA中的苯氧阴离子（在PBS溶液中）与N- gdqds的吡啶N位之间形成基态非荧光配合物来猝灭N- gdqds的荧光，使得DA具有高灵敏度和选择性，检测限（LOD）为0.14 μM，线性范围为0.32 ~ 500 μM。在电化学检测中，DA可以通过N-GDQDs/GCE在电场作用下被氧化为DA-醌，与N-GDQDs表现出较大的亲和力。DA的LOD为0.02 μM，线性范围为0.05 ~ 240 μM。最后，研究了加标法在人血清样品DA检测中的应用，结果表明该方法具有较高的准确性。我们的工作提供了一个新的基于碳量子点的传感平台，在实际应用中具有很大的潜力。
Graphdiyne quantum dots (GDQDs) have attracted increasing attentions due to its unique electronic, optical, and electrochemical properties. However, the low conductivity and quantum yield of GDQDs limit their application. Here, nitrogen-doped graphdiyne dots (N-GDQDs) are firstly synthesized by a simple, friendly and one-step hydrothermal method. The N-GDQDs show a maximum emission at 410 nm under the excitation wavelength of 319 nm. The doping N modifies the surface defect of N-GDQDs and further greatly improves their quantum yield (from 14.6% to 48.6%). In addition, the doping N induces a strong electron transport ability and good conductivity of N-GDQDs. Subsequently, the prepared N-GDQDs are used for constructing an optical-electrochemical nanosensor for sensitive and selective detection of dopamine (DA). DA can quench the fluorescence of N-GDQDs by forming a ground-state non-fluorescent complex between phenoxy anions (in PBS solution) in DA and pyridinic N sites of N-GDQDs, which leads to a highly sensitive and selective detection of DA with a limit of detection (LOD) of 0.14 μM and a linear range of 0.32–500 μM. In the electrochemical detection, DA can be oxidized to DA-quinone under the electric field through N-GDQDs/GCE, which shows a big affinity to N-GDQDs. The LOD for DA is 0.02 μM with a linear range of 0.05–240 μM. Finally, the spiked application for DA detection in human serum samples is investigated, the results show that the method has high accuracy. Our work provides a new carbon quantum dots based sensing platform, which shows great potential in practical application.