Fabrication of hyaluronic acid hollow microneedle array
Fabrication of hyaluronic acid hollow microneedle array
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DOI：
10.35848/1347-4065/ab7312
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发表时间：
2020-03
影响因子：
1.5
通讯作者：
Shingo Terashima;Chikako Tatsukawa;Tomokazu Takahashi;Masatoshi Suzuki;S. Aoyagi
中科院分区：
文献类型：
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作者：
Shingo Terashima;Chikako Tatsukawa;Tomokazu Takahashi;Masatoshi Suzuki;S. Aoyagi
以可生物降解的透明质酸为微针阵列材料，制备了中空微针阵列。我们提出了一种方法，其中凝胶状透明质酸附着到核心，然后在干燥后释放。使用具有高拉伸强度和对透明质酸的高亲和性的聚乳酸作为芯材料。使用这种方法，我们成功地制造了一个高度安全的空心微针阵列。通过用疏水UV可固化树脂涂覆芯的尖端在针尖中形成开口。针尖的直径可以通过使用锥形芯来减小，并且针尖通过用飞秒激光切割来锐化。利用人工皮肤表面评价透明质酸空心微针的机械强度。
A hollow microneedles array using biodegradable hyaluronic acid as the material for the microneedle array was fabricated. We proposed a method in which gelatinous hyaluronic acid was affixed to a core and then released after drying. A polylactic acid which has high tensile strength and high affinity for hyaluronic acid was used as the core material. Using this method, we succeeded at fabricating a highly safe hollow microneedle array. An opening was formed in the needle tip by coating the tip of the core with a hydrophobic UV curable resin. The diameter of the needle tip could be reduced by using a conical core, and the needle tip was sharpened by cutting it with a femtosecond laser. The mechanical strength of hyaluronic acid hollow microneedle was evaluated using the surface of artificial skin.