Characteristics of COVID-19 Recurrence: A Systematic Review and Meta-Analysis.
Characteristics of COVID-19 Recurrence: A Systematic Review and Meta-Analysis.
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DOI：
10.5334/aogh.3163
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发表时间：
2021-03-24
影响因子：
2.9
通讯作者：
Hoang T
中科院分区：
文献类型：
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作者：
Hoang T
先前的研究报告了出院患者中2019冠状病毒病（COVID-19）的复发。本研究旨在通过进行系统回顾和荟萃分析来检查COVID-19复发病例的特征。对截至2020年9月19日的PubMed和Embase以及灰色文献进行了系统检索。采用随机效应模型获得康复患者的合并疾病复发率和复发病例中潜在合并症的患病率。其他特征基于个体研究的总结数据计算。最终分析共纳入41项研究，我们描述了COVID-19复发病例的流行病学特征。在3，644名从COVID-19中康复并出院的患者中，估计有15%（95%CI，12%至19%）的患者在随访期间再次出现SARS-CoV-2阳性。中国的这一比例为14%（95% CI，11%-17%），韩国为31%（95% CI，26%-37%）。在复发病例中，估计有39%（95% CI，31%-48%）的受试者至少存在一种合并症。从发病到入院，从入院到出院，从出院到RNA阳性转换的时间估计分别为4.8，16.4和10.4天。本研究总结了来自病例报告、病例系列和观察性研究的最新证据，以了解出院后COVID-19复发病例的特征。建议关注出院后的随访患者，即使已经出院隔离。
Previous studies reported the recurrence of coronavirus disease 2019 (COVID-19) among discharge patients. This study aimed to examine the characteristic of COVID-19 recurrence cases by performing a systematic review and meta-analysis. A systematic search was performed in PubMed and Embase and gray literature up to September 19, 2020. A random-effects model was applied to obtain the pooled prevalence of disease recurrence among recovered patients and the prevalence of subjects underlying comorbidity among recurrence cases. The other characteristics were calculated based on the summary data of individual studies. A total of 41 studies were included in the final analysis, we have described the epidemiological characteristics of COVID-19 recurrence cases. Of 3,644 patients recovering from COVID-19 and being discharged, an estimate of 15% (95% CI, 12% to 19%) patients was re-positive with SARS-CoV-2 during the follow-up. This proportion was 14% (95% CI, 11% to 17%) for China and 31% (95% CI, 26% to 37%) for Korea. Among recurrence cases, it was estimated 39% (95% CI, 31% to 48%) subjects underlying at least one comorbidity. The estimates for times from disease onset to admission, from admission to discharge, and from discharge to RNA positive conversion were 4.8, 16.4, and 10.4 days, respectively. This study summarized up-to-date evidence from case reports, case series, and observational studies for the characteristic of COVID-19 recurrence cases after discharge. It is recommended to pay attention to follow-up patients after discharge, even if they have been in discharge quarantine.