In vivo optical frequency domain imaging of human retina and choroid
In vivo optical frequency domain imaging of human retina and choroid
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DOI：
10.1364/oe.14.004403
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发表时间：
2006-05-15
期刊：
影响因子：
3.8
通讯作者：
Yun, Seok H.
中科院分区：
文献类型：
--
作者：
Lee, Edward C. W.;de Boer, Johannes F.;Yun, Seok H.
使用扫频激光源的光频域成像 (OFDI) 是一种新兴的第二代光学相干断层扫描 (OCT) 方法。尽管传统 OCT 广泛用于视网膜疾病诊断，但迄今为止，利用 OFDI 对眼后段进行成像尚不可能。在此，我们报告了 1050 nm 高性能扫频激光器和眼科 OFDI 系统的开发，该系统提供 18.8 kHz 的 A 线速率、2.4 mm 深度范围内 > 92 dB 的灵敏度、550 mu W 的光学曝光水平以及深度穿透脉络膜。利用这些新技术，我们展示了全面的人体视网膜、视神经盘和脉络膜体内成像。这一进展使我们能够在不静脉注射荧光染料的情况下观察体内脉络膜脉管系统，并可能为评估脉络膜以及视网膜疾病提供有用的工具。 (c) 2006 年美国光学学会。
Optical frequency domain imaging (OFDI) using swept laser sources is an emerging second-generation method for optical coherence tomography (OCT). Despite the widespread use of conventional OCT for retinal disease diagnostics, until now imaging the posterior eye segment with OFDI has not been possible. Here we report the development of a high-performance swept laser at 1050 nm and an ophthalmic OFDI system that offers an A-line rate of 18.8 kHz, sensitivity of > 92 dB over a depth range of 2.4 mm with an optical exposure level of 550 mu W, and deep penetration into the choroid. Using these new technologies, we demonstrate comprehensive human retina, optic disc, and choroid imaging in vivo. This advance enables us to view choroidal vasculature in vivo without intravenous injection of fluorescent dyes and may provide a useful tool for evaluating choroidal as well as retinal diseases. (c) 2006 Optical Society of America.