INITIATION OF ETHANOL REINFORCEMENT USING A SUCROSE-SUBSTITUTION PROCEDURE IN FOOD-SATED AND WATER-SATED RATS
INITIATION OF ETHANOL REINFORCEMENT USING A SUCROSE-SUBSTITUTION PROCEDURE IN FOOD-SATED AND WATER-SATED RATS
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DOI：
10.1111/j.1530-0277.1986.tb05120.x
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发表时间：
1986-08-01
期刊：
影响因子：
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通讯作者：
SAMSON, HH
中科院分区：
文献类型：
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作者：
SAMSON, HH
训练保持自由获取食物和水的大鼠按压杠杆以获得20%蔗糖溶液。当蔗糖溶液的呈现保持响应时，向溶液中加入低浓度的乙醇。在25个疗程中，作为强化的溶液逐渐降低蔗糖浓度，直到出现不含蔗糖的10%乙醇溶液。在此启动程序后，发现乙醇浓度高达并包括40%乙醇可维持响应。在较高的乙醇浓度下，大鼠在30分钟的时间内消耗了0.90至0.95 g/kg的乙醇剂量。当乙醇和水之间的并发选择是在操作室，大鼠响应的杠杆与10%的乙醇介绍。发现乙醇和水之间的家笼偏好在操作性乙醇经验后改变，在实验开始前大鼠对10%乙醇的可接受性增加。这种启动程序提供了另一种方式，其中乙醇强化可以在没有被剥夺食物或液体的动物中被激发。据推测，当采用口服途径时，可能调节乙醇的血管内和胃内自我给药的机制也可能起作用。
Rats, maintained on free access to both food and water, were trained to press a lever to obtain a 20% sucrose solution. When presentation of the sucrose solution was maintaining responding, low ethanol concentrations were added to the soluton. Over 25 sessions, the solution presented as reinforcement was gradually reduced in sucrose concentration until a 10% ethanol solution with no sucrose was presented. Following this initiation procedure, ethanol concentrations up to and including 40% ethanol were found to maintian responding. At the higher ethanol concentrations, the rats consumed doses of ethanol between 0.90 and 0.95 g/kg in the 30-min session. When a concurrent choice between ethanol and water was available in the operant chamber, the rats responded on the lever associated with 10% ethanol presentation. Home cage preference between ethanol and water was found to be altered following the operant ethanol experience with the rats acceptability for 10% ethanol increased prior to the start of the experiment. This initiation procedure provides another manner in which ethanol reinforcement can be instigated in animals that have not been either food- or fluid-deprived. It is hypothesized that mechanisms which may regulate the intravascular and intragastric self-administrtion of ethanol may also be operating when the oral route is employed.