RELATIONSHIP BETWEEN AXONAL REGENERATION AND VASCULARITY IN TUBULATION - AN EXPERIMENTAL-STUDY IN RATS
RELATIONSHIP BETWEEN AXONAL REGENERATION AND VASCULARITY IN TUBULATION - AN EXPERIMENTAL-STUDY IN RATS
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DOI：
10.1016/0168-0102(95)00923-h
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发表时间：
1995-08-01
影响因子：
2.9
通讯作者：
YAMAMURO, T
中科院分区：
文献类型：
--
作者：
KAKINOKI, R;NISHIJIMA, N;YAMAMURO, T
本研究探讨了神经导管的血管性对周围神经再生的影响。采用间隙为10mm的大鼠坐骨神经制备，比较了三种不同类型的管（空管、含血管管和结扎血管管）的效果。管化术后6周和12周，含血管管的神经再生效率高于其他管，但24周后三种管间差异无统计学意义。电生理、组织学和微血管造影研究表明，预先插入神经导管的血管通过管内快速的毛细血管形成加速了轴突的再生。
This study investigated the effect of vascularity in a nerve conduit on peripheral nerve regeneration. The effect of three different types of tube (empty, blood vessel-containing and ligated vessel-containing) was compared using a rat sciatic nerve preparation with a 10-mm gap. Nerve regeneration through the vessel-containing tube was more efficient than in the other tubes 6 and 12 weeks after tubulation surgery, but there were no statistically significant differences among the three types of tube after 24 weeks. Electrophysiological, histological and microangiographic studies showed that vessels which were preinserted in the nerve conduit accelerated axonal regeneration through rapid capillary formation in the tube.