Effects of scopolamine and D-cycloserine on non-spatial reference memory in rats
Effects of scopolamine and D-cycloserine on non-spatial reference memory in rats
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DOI：
10.1016/s0166-4328(01)00318-7
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发表时间：
2002-02-01
影响因子：
2.7
通讯作者：
Myhrer, T
中科院分区：
文献类型：
--
作者：
Andersen, JM;Lindberg, V;Myhrer, T
本研究采用三选择同时辨别亮度的方法，考察东莨菪碱（0.5 mg/kg）单独和不同浓度d -环丝氨酸（DCS）（5、15和50 mg/kg）联合处理大鼠非空间参考记忆的保留情况。发现东莨菪碱在保留测试前给予I h会增加错误数量和达到标准所需的试验次数。三种剂量的DCS显著降低了这种增加，并形成u型剂量-反应曲线，其中15 mg/kg比5和50 mg/kg具有更强的补偿作用。进行对照实验以确认观察到的反应不是由于非助记因素。我们的研究结果表明，东莨菪碱和DCS对非空间参考记忆的影响与空间参考记忆的影响相似。(C) 2002 Elsevier Science B.V.版权所有
The aim of the present work was to use a three-choice simultaneous brightness discrimination test to examine the retention of non-spatial reference memory in rats treated with scopolamine (0.5 mg/kg) alone and in combination with various concentrations Of D-cycloserine (DCS) (5, 15 and 50 mg/kg). Scopolamine given I h before testing for retention was found to increase both the number of errors and the number of trials necessary to reach criterion. The three doses of DCS reduced this increase significantly and resulted in a U-shaped dose-response curve, where 15 mg/kg had a stronger compensatory effect than both 5 and 50 mg/kg. Control experiments were performed to confirm that the observed response was not due to non-mnemonic factors. Our results indicate that scopolamine and DCS affect non-spatial reference memory in a similar manner as shown for spatial reference memory. (C) 2002 Elsevier Science B.V. All rights reserved.