Self-affinity and lacunarity of chromatin texture in benign and malignant breast epithelial cell nuclei
Self-affinity and lacunarity of chromatin texture in benign and malignant breast epithelial cell nuclei
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DOI：
10.1103/physrevlett.80.397
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发表时间：
1998-01-12
影响因子：
8.6
通讯作者：
Gil, J
中科院分区：
文献类型：
--
作者：
Einstein, AJ;Wu, HS;Gil, J
提出了用于表征任意形状图像的自仿射性和空隙性的方法。乳腺上皮细胞核中的染色质外观被证明是统计自仿射的。光谱和Minkowski尺寸是较小的恶性病例的细胞核比良性病例的细胞核，和空隙进一步量化的形态差异，如染色质凝集和核仁。分形纹理特征是乳腺癌细胞学诊断的基础。
Methods are presented for characterizing the self-affinity and lacunarity of arbitrarily shaped images. Chromatin appearance in breast epithelial cell nuclei is shown to be statistically self-affine. Spectral and Minkowski dimensions are lesser in nuclei of malignant cases than in nuclei of benign cases, and lacunarity further quantifies morphologic differences such as chromatin clumping and nucleoli. Fractal texture features are used as the basis for an accurate cytologic diagnosis of breast cancer.