Comparison of SAT-1 foot-and-mouth disease virus isolates obtained from East Africa between 1971 and 2000 with viruses from the rest of sub-Saharan Africa
Comparison of SAT-1 foot-and-mouth disease virus isolates obtained from East Africa between 1971 and 2000 with viruses from the rest of sub-Saharan Africa
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DOI：
10.1007/s00705-006-0893-x
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Vosloo, W.
中科院分区：
文献类型：
--
作者：
Sahle, M.;Dwarka, R. M.;Vosloo, W.
SAT-I型口蹄疫似乎是撒哈拉以南非洲许多国家的地方病。使用ID基因的51 SAT-1菌株从东部，西部和南部非洲的系统发育分析表明，存在至少6个谱系和II基因型与次大陆的各个地理区域之间的联系。在东非国家之间观察到差异，这是本研究的主要重点，个别国家爆发属于不同基因型的分离株，这是菌株重新引入和爆发病毒长期传播的证据。观察到的变化量对次大陆的疾病控制具有重要意义。
Foot-and-mouth disease serotype SAT-I seems to be endemic in many sub-Saharan African countries. Phylogenetic analysis using the ID gene of 51 SAT-1 isolates from East, West and southern Africa indicated the presence of at least 6 lineages and I I genotypes with linkages between various geographical regions of the subcontinent. Differences were observed between countries in East Africa, the main focus of this study, with individual countries suffering outbreaks from isolates belonging to various genotypes, which is evidence of reintroduction of strains and long-term circulation of outbreak viruses. The amount of variation observed has significant implications for disease control on the subcontinent.