Elevated Plasma Level of Soluble F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) in Hypertension
Elevated Plasma Level of Soluble F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) in Hypertension
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DOI：
10.1038/ajh.2009.23
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发表时间：
2009-05-01
影响因子：
3.2
通讯作者：
Cheung, Bernard M. Y.
中科院分区：
文献类型：
--
作者：
Ong, Kwok Leung;Leung, Raymond Y. H.;Cheung, Bernard M. Y.
研究背景F11受体（F11 R，也称为连接粘附分子A（JAM-A））在大鼠高血压的发生发展中起重要作用。人类F11 R基因的遗传变异被证明会影响收缩压.在本研究中，方法采用酶联免疫吸附法检测152例高血压患者和166例正常血压者血浆可溶性F11 R水平，并对其中7个SNP位点进行分析。血浆sF 11 R水平在高血压患者中显著高于正常血压患者（中位数（四分位数）范围）：162.8（85.5-293.2）与116.5（74.1-194.8）pg/ml，P = 0.004），在校正年龄、性别、体重指数（BMI）后，胰岛素抵抗稳态模型（HOMA-IR）（P = 0.028）。在逐步多元Logistic回归分析中，sF 11 R水平（对数转换）（P = 0.040）、甘油三酯（对数转换）（P = 0.024）和HOMA-IR（对数转换）（P < 0.001）与高血压独立相关。血浆sF 11 R水平与收缩压和舒张压相关（分别为r = 0.15，P < 0.001和r = 0.13，P = 0.024）。多元逐步回归分析显示，高血压（P = 0.013）和纤维蛋白原（P = 0.027）是sF 11 R水平的独立预测因子。一个7位点的单倍型，目前在2.1%的受试者，与较高的sF 11 R水平（P = 0.024）。
BACKGROUNDThe F11Receptor (F11R, also known as junctional adhesion molecule A (JAM-A)) plays a role in the development of hypertension in rat. Genetic variants in the human F 11 R gene were demonstrated to influence systolic blood pressure. In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients.METHODSPlasma sF11R was measured by enzyme-linked immunosorbent assay in 152 hypertensive and 166 normotensive subjects in whom seven tagging single-nucleotide polymorphisms (SNPs) in the F11R gene had been genotyped.RESULTSPlasma sF11R levels were significantly higher in hypertensive subjects than in normotensive subjects (median (interquartile) range): 162.8 (85.5-293.2) vs. 116.5 (74.1-194.8) pg/ml, P = 0.004), which remained significantly higher after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.028). In stepwise multiple logistic regression, sF11R level (log-transformed) (P = 0.040), triglycerides (log-transformed) (P = 0.024), and HOMA-IR (log-transformed) (P < 0.001) were independently associated with hypertension. Plasma sF11R level correlated with systolic and diastolic blood pressures (r = 0.15, P < 0.001, and r = 0.13, P = 0.024, respectively). In stepwise multiple linear regression, hypertension (P = 0.013) and fibrinogen levels (P = 0.027) were significant independent predictors of sF11R level. A seven-locus haplotype, present in 2.1% of the subjects, was associated with higher sF11R level (P = 0.024).CONCLUSIONSThese results further support a role of F11 receptor in the pathophysiology of human hypertension.