Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc
Synergistic activation of the mkp-1 gene by protein kinase A signaling and USF, but not c-Myc
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DOI：
10.1016/s0014-5793(00)01566-0
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发表时间：
2000-06-02
期刊：
影响因子：
3.5
通讯作者：
Lüscher, B
中科院分区：
文献类型：
--
作者：
Sommer, A;Burkhardt, H;Lüscher, B
丝裂原活化蛋白激酶磷酸酶1（MKP-1）负调节丝裂原活化蛋白激酶，因此参与早期信号传导过程。mkp-1基因的表达受生长因子和应激的诱导。人和鼠mkp-1基因的启动子含有几个保守的DNA。结合元件，包括两个cAMP反应元件和一个E盒。我们观察到，上游刺激因子（USF），而不是c-Myc，激活mkp-1。USF与蛋白激酶A协同作用，从而为E盒在mkp-1的信号调节刺激过程中的作用提供了证据。(C)2000年欧洲生物化学学会联合会。
Mitogen-activated protein kinase phosphatase 1 (MKP-1) is negatively regulating mitogen-activated protein kinases and is therefore involved in early signaling processes. The expression of the mkp-1 gene is induced by growth factors and stress. The promoters of the human and murine mkp-1 genes contain several conserved DNA. binding elements, including two cAMP response elements and an E box. We observed that the upstream stimulatory factor (USF), but not c-Myc, activated mkp-1. USF synergized with protein kinase A, thus providing evidence for a role of the E box, during signal-regulated stimulation of mkp-1. (C) 2000 Federation of European Biochemical Societies.