The Role of Obesity in Kidney Transplantation Outcome
The Role of Obesity in Kidney Transplantation Outcome
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DOI：
10.1016/j.transproceed.2012.06.043
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发表时间：
2012-09-01
影响因子：
0.9
通讯作者：
Veroux, M.
中科院分区：
文献类型：
--
作者：
Grosso, G.;Corona, D.;Veroux, M.
背景肥胖的肾移植候选人的数量一直在增长。然而，关于肥胖对肾移植结果的影响，存在相互矛盾的结果。本研究的目的是通过使用连续与分类BMI值作为肾移植的独立危险因素来研究体重指数（BMI）与移植物存活率之间的关系。我们回顾性分析了376例肾移植受者，以评估移植时正常体重、超重和肥胖患者的移植物和患者存活率，并将BMI作为分类变量。肥胖患者更可能是男性，年龄比正常体重的受体（P = 0.021; P = 0.002;分别）。与非肥胖受者相比，肥胖受者的移植物丢失率明显较高。肥胖患者1年（76.9% vs 35.3%; P = 0.024）和3年（46.2% vs 11.8%; P = 0.035）生存率显著低于非肥胖患者。肥胖可能是移植物丢失和患者死亡的独立危险因素。仔细选择移植前体重减轻的患者是降低移植后早期并发症发生率和改善长期预后的必要条件。
Background. The number of obese kidney transplant candidates has been growing. However, there are conflicting results regarding to the effect of obesity on kidney transplantation outcome. The aim of this study was to investigate the association between the body mass index (BMI) and graft survival by using continuous versus categoric BMI values as an independent risk factor in renal transplantation.Methods. We retrospectively reviewed 376 kidney transplant recipients to evaluate graft and patient survivals between normal-weight, overweight, and obese patients at the time of transplantation, considering BMI as a categoric variable.Results. Obese patients were more likely to be male and older than normal-weight recipients (P = .021; P = .002; respectively). Graft loss was significantly higher among obese compared with nonobese recipients. Obese patients displayed significantly lower survival compared with nonobese subjects at 1 year (76.9% vs 35.3%; P = .024) and 3 years (46.2% vs 11.8%; P = .035).Conclusions. Obesity may represent an independent risk factor for graft loss and patient death. Careful patient selection with pretransplantation weight reduction is mandatory to reduce the rate of early posttransplantation complications and to improve long-term outcomes.