Experimental rubella. Clinical and laboratory findings.
Experimental rubella. Clinical and laboratory findings.
复制标题
实验性风疹。
DOI：
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发表时间：
1965
影响因子：
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通讯作者：
R. Huebner
中科院分区：
文献类型：
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作者：
G. Schiff;J. Sever;R. Huebner
自从Gregg的初步观察1以来，妊娠早期母体风疹感染的不良影响已得到充分认识。虽然风疹一直被认为是病毒性病因，但直到最近才描述了在组织培养中分离病毒和检测患者中的中和抗体。2-4随着这些方法的可用性，已经有可能进行详细的研究，将实验室发现与实验产生的疾病的临床过程相关联。这种类型的研究可以提供对疾病的更好的理解，从而提供更智能的预防方法，并可能最终控制疾病。本调查描述了临床和实验室的结果，年轻的成年人实验性鼻内感染组织培养生长风疹病毒。材料与方法本研究作为三项志愿者研究的一部分进行
SINCE the initial observations of Gregg, 1 the adverse effects resulting from maternal rubella infection during the early part of pregnancy have been well recognized. Although rubella has been assumed to be of viral etiology, it was not until recently that the isolation of the virus in tissue culture and the detection of neutralizing antibody in patients was described. 2-4 With the availability of these methods, it has become possible to conduct detailed studies correlating the laboratory findings with the clinical course of experimentally produced disease. Studies of this type can provide a better understanding of the disease, and hence a more intelligent approach to the prophylaxis, and perhaps eventually the control of the disease. The present investigation describes the clinical and laboratory findings for young adults following experimental intranasal infection with tissue culture grown rubella virus. Materials and Methods This investigation was undertaken as part of three volunteer studies