Nine Cases of SARS-CoV-2-PCR-positive Samples Showed No Increase of Antibodies Against SARS-CoV-2
Nine Cases of SARS-CoV-2-PCR-positive Samples Showed No Increase of Antibodies Against SARS-CoV-2
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DOI：
10.21873/invivo.12587
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发表时间：
2021
期刊：
影响因子：
2.3
通讯作者：
Takao Kitagawa;Masanobu Kobayashi;Tohru Ohta;Masaru Terasaki;Y. Tsukamoto;R. Takai;Reika Ishizumi;O. Uehara;K. Nakagawa;K. Akino;M. Asaka;Y. Kuramitsu
中科院分区：
文献类型：
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作者：
Takao Kitagawa;Masanobu Kobayashi;Tohru Ohta;Masaru Terasaki;Y. Tsukamoto;R. Takai;Reika Ishizumi;O. Uehara;K. Nakagawa;K. Akino;M. Asaka;Y. Kuramitsu
背景/目标：自 2020 年 2 月下旬至今，严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 一直影响日本北海道。本研究的目的是通过分析抗 SARS-CoV-2 抗体（IgG 和总 Ig）来报告抗 SARS-CoV-2 抗体阳性与 SARS-CoV-2 PCR 阳性病例之间的关系。患者和方法：从发生病毒爆发的两家疗养院和两家医院的护理人员和护士那里收集了血清样本。通过 RT-qPCR 确认所有人员均呈 SARS-CoV-2 阳性，并分析了他们的血清中的抗 SARS-CoV-2 抗体（IgG 和总 Ig）。结果：尽管 43 个样本中的 34 个样本 (79.1%) 显示出足够量的抗 SARS-CoV-2 抗体，但 9 个 RT-qPCR 阳性样本 (20.9%) 显示其血清中不存在抗 SARS-CoV-2 抗体。结论：20.9% 的 SARS-CoV-2 RT-qPCR 阳性样本显示不存在抗 SARS-CoV-2 抗体，这提供了先天免疫反应可以消除病毒而不激活适应性免疫反应的可能性。
Background/Aim: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been affecting Hokkaido, Japan since late February 2020 until present. The aim of this study was to report the relationship between anti-SARS-CoV-2 antibody-positive and SARS-CoV-2 PCR-positive cases by analyzing anti-SARS-CoV-2 antibodies (IgG and total-Ig). Patients and Methods: Serum samples were collected from care workers and nurses in two nursing homes and two hospitals which underwent virus outbreak. All people were confirmed to be SARS-CoV-2-positive by RT-qPCR and their sera was analyzed for anti-SARS-CoV-2 antibodies (IgG and total-Ig). Results: Although 34 out of 43 samples (79.1%) showed enough amount of anti-SARS-CoV-2 antibodies, 9 RT-qPCR -positive samples (20.9%) showed absence of anti-SARS-CoV-2 antibodies in their sera. Conclusion: The results that 20.9% of RT-qPCR-positive samples with SARS-CoV-2 showed absence of anti-SARS-CoV-2 antibodies provides a possibility that the innate immune reaction could eliminate the virus without activating adaptive immune reaction.