Human antibody responses to lipopolysaccharide after meningitis due to Haemophilus influenzae type b.
Human antibody responses to lipopolysaccharide after meningitis due to Haemophilus influenzae type b.
复制标题
b 型流感嗜血杆菌脑膜炎后人体抗体对脂多糖的反应。
DOI：
10.1093/infdis/145.2.181
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Granoff,DM
中科院分区：
文献类型：
--
作者：
Shenep,JL;MunsonJr,RS;Granoff,DM
应用酶联免疫吸附试验检测了27例B型流感嗜血杆菌脑膜炎患者急性期和恢复期血清中脂多糖（LPS）抗体水平。急性期血清中LPS抗体的几何平均滴度与24名对照儿童和22名健康成人相似。在恢复期血清中，LPS的IgG和IgM抗体的几何平均滴度增加了四倍。抗体应答与年龄和对B型胶囊的抗体应答无关。然而，反应是双峰：儿童IgG和IgM抗体高水平的LPS在急性期血清没有响应进一步增加血清抗体LPS感染后，而儿童较低的初始水平显示高反应。在半数急性病患儿的血清中存在高水平的LPS抗体，这表明某些LPS决定簇的抗体不具有保护作用。
Levels of serum antibodies to lipopolysaccharide (LPS) were measured in acute- and convalescent-phase sera from 27 patients with meningitis due toHaemophilus influenzaetype b using an enzyme-linked immunosorbent assay. The geometric mean titers of antibodies to LPS in acute-phase sera were similar to those of 24 control children and 22 healthy adults. In convalescent-phase sera there was a fourfold increase in the geometric mean titers of IgG and IgM antibodies to LPS. The antibody responses were independent of age and of antibody response to the type b capsule. However, the responses were bimodal: children with high levels of IgG and IgM antibodies to LPS in acutephase sera did not respond with further increases in serum antibodies to LPS after infection, whereas children with lower initial levels showed high responses. The presence of high levels of antibodies to LPS in the sera of half of the acutely ill children suggest that antibodies to some LPS determinants are not protective.