Effects of osmotically driven cell volume changes on diffusion-weighted imaging of the rat optic nerve
Effects of osmotically driven cell volume changes on diffusion-weighted imaging of the rat optic nerve
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DOI：
10.1002/mrm.1910350206
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发表时间：
1996-02-01
影响因子：
3.3
通讯作者：
Gore, JC
中科院分区：
文献类型：
--
作者：
Anderson, AW;Zhong, JH;Gore, JC
使用磁共振成像在体外测量大鼠视神经的表观扩散系数（ADC），以确定细胞体积分数的变化对组织水扩散的影响。在细胞膜去极化和（i）增加的细胞内体积、（ii）减少的细胞内体积和（iii）可忽略的体积变化的条件下测定神经ADC。单独去极化对ADC几乎没有影响，而体积变化产生强烈的可逆效应。细胞体积增加会降低ADC，反之亦然。这些结果与细胞外间隙的变化是脑组织ADC变化的主要来源的观点一致。
The apparent diffusion coefficient (ADC) of the rat optic nerve was measured in vitro, using magnetic resonance imaging, to determine the effects of changes in cellular volume fraction on the diffusion of tissue water, Nerve ADC was determined under conditions of cell membrane depolarization and (i) increased intracellular volume, (ii) decreased intracellular volume, and (iii) negligible volume change. Depolarization alone had little affect on ADC, whereas volume changes produced strong, reversible effects, Increased cell volume decreased ADC and vice versa. These results are consistent with the view that changes in the extracellular space are the major source of ADC changes in brain tissue.