BLEPHAROSPASM - A REVIEW OF 264 PATIENTS
BLEPHAROSPASM - A REVIEW OF 264 PATIENTS
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DOI：
10.1136/jnnp.51.6.767
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发表时间：
1988-06-01
影响因子：
11
通讯作者：
MARSDEN, CD
中科院分区：
文献类型：
--
作者：
GRANDAS, F;ELSTON, J;MARSDEN, CD
对264例眼睑痉挛患者的自然病程和对不同治疗的反应进行了评价。平均发病年龄为55.8岁，女性发病率为1.8：1。在78%的患者中发现了其他部位的肌张力障碍，通常在颅颈区域，并且似乎遵循躯体部位进展。在9.5%的病例中发现了眼睑痉挛或肌张力障碍的家族史，这表明遗传易感性。12.1%的病例中眼部病变是眼睑痉挛发作的先兆。对药物的反应是不一致的，虽然最初的改善经历了五分之一的患者与抗胆碱能药物治疗。双侧面神经撕脱伤29例，手术成功27例，术后复发22例，平均1年。在151名患者中进行了肉毒杆菌毒素注射。118例患者病情明显好转。平均获益时间为9.2周。最常见的副作用为一过性上睑下垂和复视。
The natural history and response to different treatments have been evaluated in 264 patients with blepharospasm. The mean age of onset was 55.8 years and there was a female preponderance of 1.8 to 1. Dystonia elsewhere was found in 78% of patients, usually in the cranial-cervical region, and appeared to follow a somatotopic progression A family history of blepharospasm or dystonia elsewhere was found in 9.5% of cases, which suggests a genetic predisposition. Ocular lesions preceeded the onset of blepharospasm in 12.1% of cases. The response to drugs was inconsistent, although initial improvement was experienced by one fifth of patietns treated with anticholinergics. Twenty-nine bilateral facial nerve avulsion operations were performed with benefit in 27 cases; but recurrences appeared in 22, on average one year after surgery. Botulinum toxin injections were performed in 151 patients. Significant improvement was achieved in 118 cases. Mean duration of benefit was 9.2 weeks. Transiet ptosis and diplopia were the commonest side effects.