β-carotene with vitamins E and C offers synergistic cell protection against NOx
β-carotene with vitamins E and C offers synergistic cell protection against NOx
复制标题
DOI：
10.1016/s0014-5793(98)01173-9
复制
发表时间：
1998-10-09
期刊：
影响因子：
3.5
通讯作者：
Truscott, TG
中科院分区：
文献类型：
--
作者：
Böhm, F;Edge, R;Truscott, TG
过氧亚硝酸根阴离子和二氧化氮（自由基）是重要的有毒物质，可在体内由一氧化氮产生。在维生素E和维生素C存在下，证明了β-胡萝卜素的体内和体外细胞保护作用。与单独的抗氧化剂相比，观察到协同保护作用，这可以用电子转移反应来解释，其中β-胡萝卜素自由基被维生素C修复。(C)1998年欧洲生物化学学会联合会。
The peroxynitrite anion and the nitrogen dioxide (radical) are important toxic species which can arise in vivo from nitric oxide, Both in vivo and in vitro cell protection is demonstrated for beta-carotene in the presence of vitamin E and vitamin C. A synergistic protection is observed compared to the individual anti-oxidants and this is explained in terms of an electron transfer reaction in which the p-carotene radical is repaired by vitamin C. (C) 1998 Federation of European Biochemical Societies.