Postural tachycardia syndrome following human papillomavirus vaccination
Postural tachycardia syndrome following human papillomavirus vaccination
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DOI：
10.1111/ene.12272
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发表时间：
2014-01-01
影响因子：
5.1
通讯作者：
Blitshteyn, S.
中科院分区：
文献类型：
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作者：
Blitshteyn, S.
背景和目的体位性心动过速综合征（Postural tachycardia syndrome，POTS）是一种异质性自主神经系统疾病，可能有自身免疫性病因。Methods6例在人乳头瘤病毒疫苗接种后6天至2个月内新发POTS的患者报告了3例神经心源性晕厥，3例被诊断为可能的小纤维神经病。所有患者的症状改善超过3年的药物治疗和非药物措施，但残留症状持续存在。分子模拟与形成交叉反应的自身抗体的自主神经节，神经元，心脏蛋白或血管受体的潜在目标被认为是一个可能的发病机制，新的发病POTS后immunos.Conclusioncorrectly诊断POTS和认识，POTS可能会发生在年轻女性接种疫苗后，这种情况是必要的，及时和有效的管理。
Background and purposePostural tachycardia syndrome (POTS) is a heterogeneous disorder of the autonomic nervous system that may have an autoimmune etiology.MethodsSix patients who developed new onset POTS 6days to 2months following human papillomavirus vaccination are reported.ResultsThree patients also had neurocardiogenic syncope, and three patients were diagnosed with possible small fiber neuropathy. Symptoms in all patients improved over 3years with pharmacotherapy and non-pharmacological measures but residual symptoms persisted. Molecular mimicry with formation of cross-reacting autoantibodies to the potential targets of the autonomic ganglia, neurons, cardiac proteins or vascular receptors is considered as a possible pathogenesis of new onset POTS after immunization.ConclusionCorrect diagnosis of POTS and awareness that POTS may occur after vaccination in young women is essential for prompt and effective management of this condition.