Chlorpromazine equivalent doses for the newer atypical antipsychotics
Chlorpromazine equivalent doses for the newer atypical antipsychotics
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DOI：
10.4088/jcp.v64n0607
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发表时间：
2003-06-01
影响因子：
5.3
通讯作者：
Woods, SW
中科院分区：
文献类型：
--
作者：
Woods, SW
背景：一些临床和研究应用需要估计抗精神病药物的治疗剂量等效性。由于新的非典型抗精神病药物的出现，新的剂量当量estimates has been needed.Method：报告的最低有效剂量确定为每个新的非典型抗精神病药物和氟哌啶醇在所有可用的固定剂量安慰剂对照研究。然后使用“2 mg氟哌啶醇等于100 mg氯丙嗪”的惯例将报告的氟哌啶醇的最小有效剂量当量比转换为氯丙嗪当量。数据来源和研究选择：为了确定固定剂量研究，检索了以下来源，直到2002年6月：MEDLINE、已识别报告的参考书目、已发表的荟萃分析和综述、科克伦综述、可从食品和药物管理局获得的信息自由法案材料，结果：氯丙嗪100 mg/d的等效剂量分别为利培酮2 mg/d，奥氮平5 mg/d，喹替鲁胺75 mg/d，齐拉西酮60 mg/d，阿立哌唑7.5 mg/d。剂量等效性估计的来源是基于证据的，并且在药物之间是一致的。
Background: Several clinical and research applications require an estimation of therapeutic dose equivalence across antipsychotic medications. Since the advent of the newer atypical antipsychotics, new dose equivalent estimations have been needed.Method: The reported minimum effective dose was identified for each newer atypical antipsychotic medication and for haloperidol across all available fixed-dose placebo-controlled studies. Reported minimum effective dose equivalence ratios to haloperidol were then converted to chlorpromazine equivalents using the "2 mg of haloperidol equals 100 mg of chlorpromazine" convention.Data Sources and Study Selection: To identify the fixed-dose studies, the following sources were searched until June 2002: MEDLINE, the bibliographies of identified reports, published meta-analyses and reviews, Cochrane reviews, Freedom of Information Act material available from the Food and Drug Administration, and abstracts from several scientific meetings from 1997 to 2002.Results: Doses equivalent to 100 mg/day of chlorpromazine were 2 mg/day for risperidone, 5 mg/day for olanzapine, 75 mg/day for quetiapine, 60 mg/day for ziprasidone, and 7.5 mg/day for aripiprazole.Conclusion: These equivalency estimates may be useful for clinical and research purposes. The source of the dose equivalency estimation is evidence-based and consistent across medication.