Alkaloids from Melodinus yunnanensis
Alkaloids from Melodinus yunnanensis
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云南麦洛丁生物碱
DOI：
10.1016/j.phytochem.2012.06.013
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发表时间：
2012-11-01
期刊：
影响因子：
3.8
通讯作者：
Luo, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Cai, Xiang-Hai;Li, Yan;Luo, Xiao-Dong
分离得到10个单萜类吲哚生物碱，分别为：蜜环素、19S-甲氧基管酮N-氧化物、16，19-环氧基-三角洲(14)-乙烯醇、14β-羟基莫洛宁、甲柳宁、三角洲(14)-长春花碱N-4-氧化物、16β，21β-环氧长春花碱、14β，15β-20S-奎拉明、3-氧代-鬼臼碱、2α，7-二羟基-二氢呋喃甲碱，以及32个已知生物碱。通过一维和二维核磁共振、傅立叶变换红外光谱、紫外光谱和质谱学数据确证了它们的结构。对四种人癌细胞株：Mcf-7乳腺癌、SMMC-7721肝细胞癌、HL-60髓系白血病和A-549肺癌显示出较弱的细胞毒活性。(C)2012爱思唯尔有限公司。保留所有权利。
Ten monoterpenoid indole alkaloids, namely meloyine, 19S-methoxytubotaiwine N-4-oxide, 16,19-epoxy-Delta(14)-vincanol, 14 beta-hydroxymeloyunine, meloyunine, Delta(14)-vincamenine N-4-oxide, 16 beta,21 beta-epoxy-vincadine, 14 beta,15 beta-20S-quebrachamine, 3-oxo-voaphylline, 2 alpha,7 alpha-dihydroxy-dihydrovoaphylline, and 32 known alkaloids were isolated from leaves and twigs of Melodious yunnanensis. Their structures were elucidated based on 1- and 2-D NMR, FTIR, UV, and MS spectroscopic data. Meloyine I showed weak cytotoxic activity against four human cancer cell lines: MCF-7 breast cancer, SMMC-7721 hepatocellular carcinoma, HL-60 myeloid leukemia, and A-549 lung cancer. (C) 2012 Elsevier Ltd. All rights reserved.