Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease Cutoff Values and Diagnostic Accuracy of Quantitative [15O]H2O PET Imaging
Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease Cutoff Values and Diagnostic Accuracy of Quantitative [15O]H2O PET Imaging
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DOI：
10.1016/j.jacc.2014.05.069
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发表时间：
2014-10-07
影响因子：
24
通讯作者：
Knuuti, Juhani
中科院分区：
文献类型：
--
作者：
Danad, Ibrahim;Uusitalo, Valtteri;Knuuti, Juhani
背景：最近的研究表明，当心肌血流量（MBF）以绝对值量化时，检测冠状动脉疾病（CAD）的诊断准确性有所提高，但对于血流动力学显著的CAD没有统一接受的截止值。本研究的目的是确定绝对MBF的截止值，并评估定量[O-15]H2O正电子发射断层扫描（PET）的诊断准确性。方法共330例患者进行定量[O-15] H2O PET成像和有创冠状动脉造影术结合血流储备分数测量。狭窄>90%和/或血流储备分数
BACKGROUND Recent studies have demonstrated improved diagnostic accuracy for detecting coronary artery disease (CAD) when myocardial blood flow (MBF) is quantified in absolute terms, but there are no uniformly accepted cutoff values for hemodynamically significant CAD. OBJECTIVES The goal of this study was to determine cutoff values for absolute MBF and to evaluate the diagnostic accuracy of quantitative [O-15]H2O positron emission tomography (PET).METHODS A total of 330 patients underwent both quantitative [O-15]H2O PET imaging and invasive coronary angiography in conjunction with fractional flow reserve measurements. A stenosis >90% and/or fractional flow reserve