Sugar-originated carbon nanodots selectively damage the tumor and enhance the sensitivity of chemotherapy
Sugar-originated carbon nanodots selectively damage the tumor and enhance the sensitivity of chemotherapy
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DOI：
10.1016/j.nantod.2021.101200
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发表时间：
2021-06
期刊：
影响因子：
17.4
通讯作者：
Yi Wang;Taotao Huo;Huiling Jiang;Yibo Xie;Xiaoyi Zhang;Huifang Nie;Yafeng Yang;Min Qian;Wenshuai Li;Tingting Hao;Wei Guo;Yanhui Qin;J. Shi;Wei Shi;Rongqin Huang
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文献类型：
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作者：
Yi Wang;Taotao Huo;Huiling Jiang;Yibo Xie;Xiaoyi Zhang;Huifang Nie;Yafeng Yang;Min Qian;Wenshuai Li;Tingting Hao;Wei Guo;Yanhui Qin;J. Shi;Wei Shi;Rongqin Huang
阻断肿瘤能量代谢有望成为一种潜在的肿瘤治疗策略。然而，开发一种单一的、简单的、直接阻断肿瘤能量代谢的、具有良好生物安全性和临床应用潜力的纳米颗粒系统仍然缺乏。本文描述了一种用于制备糖源性碳纳米点（sCND）的技术，其灵感来自于传统的红烧猪肉烹饪技巧，其中蔗糖在热植物油中焦糖化。这种特殊的制剂赋予sCND表面上的一些葡萄糖残基和光学纳米点特性，这使得GLUT1介导的神经胶质瘤靶向积累能够通过体内成像进行监测。随后，sCND可以阻碍葡萄糖进入肿瘤的积极摄取。这阻断了肿瘤能量代谢，损害了肿瘤生长，并增强了对化疗的敏感性，如两种肿瘤模型（神经胶质瘤和肝癌）所示。此外，这种碳纳米点具有良好的生物安全性，包括低细胞毒性，几乎没有血液毒性和组织损伤潜力。它是可食用的，由于特殊的准备和结构类似于传统的烹饪风格。这项工作报告了一种简单的方法来生产具有良好生物分布和生物安全性的先进治疗性碳纳米点，这将为未来临床应用的强大平台铺平道路。
Blocking the tumor energy metabolism is expected to be a potential cancer treatment strategy. However, developing a single and simple nanoparticle system to directly block the tumor energy metabolism with good biosafety and high potential for clinical application remains absence. Herein, a technique is described for the preparation of sugar-originated carbon nanodots (sCND) which is inspired by the traditional cooking skill of pork braised in brown sauce, where the sucrose caramelizes in the hot vegetable oil. The special preparation endows sCND with some glucose residues on their surfaces and optical nanodot properties, which enable the GLUT1-mediated glioma-targeted accumulation that can be monitored by in vivo imaging. Subsequently, sCND can hamper the avid uptake of glucose into the tumor. This blocks the tumor energy metabolism, impairs tumor growth and enhances sensitivity to chemotherapy as shown in two tumor models (glioma and hepatoma). Additionally, this kind of carbon nanodots possesses a favorable biosafety profile, including low cytotoxicity, almost no hematotoxicity and tissue damaging potential. It is edible due to the special preparation and structure similar to the traditional cooking style. This work reports a simple method to produce advanced therapeutic carbon nanodots with favorable biodistribution and biosafety, which will pave the way for a powerful platform with future clinical applications.