Alteration of Tumor Microenvironment for Improved Delivery and Intratumor Distribution of Nanocarriers
Alteration of Tumor Microenvironment for Improved Delivery and Intratumor Distribution of Nanocarriers
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DOI：
10.1248/bpb.b13-00121
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发表时间：
2013-05-01
影响因子：
2
通讯作者：
Kiwada, Hiroshi
中科院分区：
文献类型：
--
作者：
Ishida, Tatsuhiro;Kiwada, Hiroshi
基于纳米载体的癌症化学治疗剂被认为通过在静脉内施用后改变药剂的药代动力学和组织分布来提高治疗效率并减少相关化学治疗剂的副作用。尽管有这些有利的性质，但基于纳米载体的癌症化疗剂并不总是有效的，因为它们的异质性肿瘤内定位。纳米载体在肿瘤中的均匀分布将提高基于纳米载体的癌症化疗剂的功效。在这篇文章中，我们描述和讨论了一些试验，试图操纵肿瘤微环境中的障碍，阻碍外渗通过肿瘤血管和渗透的纳米载体在实体瘤。与纳米载体的肿瘤内分布直接相关的肿瘤微环境的改变可能是改善基于纳米载体的癌症化疗药物递送的潜在策略。
Nanocarrier-based cancer chemotherapeutics are thought to increase therapeutic efficiency and reduce the side effects of associated chemotherapeutic agents by altering the agents' pharmacokinetics and tissue distribution following intravenous administration. In spite of these favorable properties, nanocarrier-based cancer chemotherapeutics are not always effective because of their heterogeneous intratumoral localization. Homogeneous distribution of nanocarriers in a tumor would improve the efficacy of nanocarrier-based cancer chemotherapeutics. In this article, we describe and discuss some trials that attempt to manipulate the barriers in the tumor microenvironment that hinder extravasation through the tumor vasculature and penetration of nanocarriers in solid tumors. Alterations of the tumor microenvironment that relate directly to the intratumoral distribution of nanocarriers may be potential strategies to improve the delivery of nanocarrier-based cancer chemotherapeutics.