CALLOSAL AND SUPERIOR TEMPORAL SULCUS CONTRIBUTIONS TO RECEPTIVE-FIELD PROPERTIES IN THE MACAQUE MONKEYS NUCLEUS OF THE OPTIC TRACT AND DORSAL TERMINAL NUCLEUS OF THE ACCESSORY OPTIC TRACT
CALLOSAL AND SUPERIOR TEMPORAL SULCUS CONTRIBUTIONS TO RECEPTIVE-FIELD PROPERTIES IN THE MACAQUE MONKEYS NUCLEUS OF THE OPTIC TRACT AND DORSAL TERMINAL NUCLEUS OF THE ACCESSORY OPTIC TRACT
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DOI：
10.1002/cne.903210113
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发表时间：
1992-07-01
影响因子：
2.5
通讯作者：
ILG, U
中科院分区：
文献类型：
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作者：
HOFFMANN, KP;DISTLER, C;ILG, U
为了评估皮质输入对视束核 (NOT) 和背终核 (DTN) 神经元感受野特性的功能贡献，第一组实验评估了胼胝体分裂的猴子中 NOT-DTN 细胞的反应特性。在视觉潜伏期、方向特异性、方向调节宽度、速度调节、眼优势和双眼相互作用方面，它们与正常猴子中的 NOT-DTN 神经元没有区别。然而，在感受野的范围方面发现了明显的差异。然而，在正常猴子中，NOT-DTN 感受野包括对侧半视野和中央凹以及同侧视野的大部分，而胼胝体裂猴中的感受野突然停止在或接近垂直 0 子午线，并且不延伸到同侧视野。此外，与正常动物相比，胼胝体分裂猴的感受野内最高灵敏度的位置偏离了垂直的 0 子午线。在第二组实验中，我们逆向识别了投射到 NOT-DTN 的颞上沟内的皮层神经元。这些神经元发现于MT区，大多靠近MTp或MST1的边界。所有这些都对同侧刺激运动具有方向选择性，并且它们的感受野基本上延伸到同侧视觉半视野。具有其他首选方向的神经元没有投射到 NOT-DTN。这些结果有助于解释皮质损伤后缓慢眼球运动的同向方向缺陷，以及胼胝体横断后半视野刺激下视动眼球震颤的不对称性。结果更普遍的含义是，皮层区域的特定功能只能通过了解其皮层下连接来理解。
To assess the functional contribution of the cortical input to the receptive field properties of nucleus of the optic tract (NOT) and dorsal terminal nucleus (DTN) neurons, a first set of experiments evaluated the response properties of NOT-DTN cells in monkeys with split corpus callosum. With respect to visual latency, direction specificity, directional tuning width, velocity tuning, ocular dominance, and binocular interaction, they were indistinguishable from NOT-DTN neurons in normal monkeys. However, a clear difference was found regarding the extent of the receptive fields. Whereas, in normal monkeys, NOT-DTN receptive fields include the contralateral hemifield and the fovea as well as substantial parts of the ipsilateral visual field, receptive fields in callosum-split monkeys stop abruptly at, or close to, the vertical 0-meridian and do not extend into the ipsilateral visual field. In addition, the location of the highest sensitivity within the receptive fields in callosum-split monkeys is shifted away from the vertical 0-meridian in comparison to normal animals.In a second set of experiments, we antidromically identified cortical neurons within the superior temporal sulcus that project to the NOT-DTN. These neurons were found in area MT mostly near the border of MTp or MSTl. All of them are direction selective for ipsiversive stimulus movement, and their receptive fields extend substantially into the ipsilateral visual hemifield. Neurons with other preferred directions.did not project to the NOT-DTN.These results contribute to the explanation of the ipsiversive directional deficits in slow eye movements after cortical lesions, as well as the asymmetries in optokinetic nystagmus with hemifield stimulation after transection of the corpus callosum. The more general implication of the results is that a particular function of a cortical area can only be understood by knowing its subcortical connections.