The treatment of advanced hodgkin's disease.
The treatment of advanced hodgkin's disease.
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晚期霍奇金病的治疗。
DOI：
10.1007/bf00320472
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Clarkson,BD
中科院分区：
文献类型：
--
作者：
Straus,DJ;Lee,BJ;Koziner,B;Nisce,LZ;Young,CW;Clarkson,BD
1975 年 1 月至 1978 年 12 月期间，118 名晚期霍奇金病患者接受了为期 8 个月的交替 MOPP 和阿霉素、贝洛霉素、达卡巴嗪和长春碱 (ABDV) 治疗，同时对最初涉及大块疾病的区域进行了 1 个月的低剂量放射治疗 (2,000 rad)。在 57 名可评估的既往未治疗患者中，50/57 (88%) 达到完全缓解，7/57 (12%) 达到部分缓解。自缓解之日起 36 个月时，完全缓解者的估计复发率为 16%。毒性与其他联合化疗方案相当。这些结果是治疗晚期霍奇金病患者的最佳结果之一。
Between January, 1975, and December, 1978, 118 patients with advanced Hodgkin's disease were treated with 8 months of alternating MOPP and adriamycin, belomycin, dacarbazine and vinblastine (ABDV) combined with 1 month of low-dose radiation therapy (2,000 rad) to areas initially involved with bulky disease. Among 57 evaluable previously-untreated patients, 50/57 (88%) achieved complete and 7/57 (12%) partial remissions. The estimated relapse rate among the complete responders was 16% at 36 months from date of remission. Toxicity was comparable to that of other combination chemotherapy regimens. These results are among the best reported for the treatment of patients with advanced Hodgkin's disease.