CALCIUM INFLUX REQUIREMENT FOR HUMAN NEUTROPHIL CHEMOTAXIS - INHIBITION BY LANTHANUM CHLORIDE
CALCIUM INFLUX REQUIREMENT FOR HUMAN NEUTROPHIL CHEMOTAXIS - INHIBITION BY LANTHANUM CHLORIDE
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DOI：
10.1126/science.948752
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
SNYDERMAN, R
中科院分区：
文献类型：
--
作者：
BOUCEK, MM;SNYDERMAN, R
人中性粒细胞的钙通量测定在存在的趋化活性血清显示出显着的刺激45Ca从媒体的摄取。化学活性不活跃的血清没有引起钙内流。由于激活血清的钙内流的幅度足以触发先前在肌细胞中描述的收缩系统。氯化镧抑制人中性粒细胞对活化血清的趋化反应。La的浓度，抑制趋化性也抑制激活血清引起的钙内流。这些数据支持钙内流在中性粒细胞趋化性中的直接作用。
Ca fluxes of human neutrophils measured in the presence of chemotactically active serum showed a marked stimulation of 45Ca uptake from the media. Chemotactically inactive serum did not cause an influx of Ca. The magnitude of the Ca influx due to activated serum was sufficient to trigger contractile systems previously described in muscle cells. Lanthanum chloride inhibited the chemotactic response of human neutrophils to activated serum. La in concentrations that suppressed chemotaxis also inhibited the Ca influx caused by activated serum. The data support a direct role of Ca influx in chemotaxis of neutrophils.