Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G(1) to S
Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G(1) to S
复制标题
DOI：
10.1128/jvi.70.12.8850-8857.1996
复制
发表时间：
1996-12-01
影响因子：
5.4
通讯作者：
Shenk, T
中科院分区：
文献类型：
--
作者：
Lu, MS;Shenk, T
人巨细胞病毒感染后12小时抑制人包皮成纤维细胞的生长。通过流式细胞术对受感染细胞的细胞 DNA 含量进行分析表明，巨细胞病毒不会在单个点阻止细胞周期进程。至少发生两次阻塞，其中之一发生在细胞周期的 G(1) 期。巨细胞病毒感染引起的 G(1) 停滞会阻止血清刺激后进入 S 期。
Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated that cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G(1) phase of the cell cycle. The G(1) arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.