Emerging roles of proteoglycans in cardiac remodeling.
Emerging roles of proteoglycans in cardiac remodeling.
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DOI：
10.1016/j.ijcard.2018.11.125
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发表时间：
2019-03
影响因子：
3.5
通讯作者：
Xiaoya Wang;Yi Lu;Yao Xie;Jian Shen;Meixiang Xiang
中科院分区：
文献类型：
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作者：
Xiaoya Wang;Yi Lu;Yao Xie;Jian Shen;Meixiang Xiang
心脏重构是心脏对一系列病理刺激的反应。心脏重塑最初是适应性的;然而，如果持续，它最终会导致不良的临床结果。心肌细胞丢失或肥大、炎症和纤维化是心脏重塑的标志。由糖胺聚糖和核心蛋白组成的蛋白聚糖是细胞外基质的非结构组分。蛋白聚糖的缺乏导致发育过程中的心血管缺陷。此外，新出现的证据表明，蛋白多糖作为重要的修饰剂在缺血和压力超负荷相关的心脏重塑。蛋白聚糖还可以为进一步改善心血管疾病的预后提供新的治疗策略。
Cardiac remodeling is the response of the heart to a range of pathological stimuli. Cardiac remodeling is initially adaptive; however, if sustained, it ultimately causes adverse clinical outcomes. Cardiomyocyte loss or hypertrophy, inflammation and fibrosis are hallmarks of cardiac remodeling. Proteoglycans, which are composed of glycosaminoglycans and a core protein, are a non-structural component of the extracellular matrix. The lack of proteoglycans results in cardiovascular defects during development. Moreover, emerging evidence has indicated that proteoglycans act as significant modifiers in ischemia and pressure overload-related cardiac remodeling. Proteoglycans may also provide novel therapeutic strategies for further improvement in the prognosis of cardiovascular diseases.