Connectivity and the elastic properties of cancellous bone
Connectivity and the elastic properties of cancellous bone
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DOI：
10.1016/s8756-3282(98)00164-1
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发表时间：
1999-02-01
期刊：
影响因子：
4.1
通讯作者：
Huiskes, R
中科院分区：
文献类型：
--
作者：
Kabel, J;Odgaard, A;Huiskes, R
本研究探讨了骨小梁连通性对松质骨力学质量的可能意义。共141个立方体骨小梁标本收集自56个人的尸检材料，没有任何已知的骨或转移性疾病被使用。年龄变化范围在14-91岁之间，发现了广泛的小梁结构。每个试件以20或25 μ m的体素大小进行三维重建。将详细的三维重建作为微观结构有限元模型的输入，获得小梁结构的完整弹性特性，并计算最大和平均刚度。测定了连通性密度和表面密度的体积分数和真三维建筑测量值。连接密度由欧拉数确定，欧拉数是一种拓扑性质。使用多元回归分析发现，体积分数在平均和最大刚度的变化中解释了迄今为止最大的部分（84%-94%）。当包括连通性密度和表面密度时，相关系数略有增加，达到89% ~ 95%，连通性密度的回归系数明显为负。结果表明，在正常松质骨中，连接密度对于通过形态学变量评估弹性特性的价值非常有限，但如果存在这种关系，那么刚度会随着连接的增加而降低（bone 24:15 -120; 1999） (C) 1999年由Elsevier Science Inc.提供。版权所有。
This study addresses the possible significance of trabecular connectivity for the mechanical quality of cancellous bone. A total of 141 cubic trabecular bone specimens collected from autopsy material from 56 individuals without any known bone or metastatic diseases were used. Age variation was in the range of 14-91 years and a wide range of trabecular architecture was found. Each specimen was three-dimensionally reconstructed with a voxel size of either 20 or 25 mu m. Using the detailed three-dimensional reconstructions as input for microstructural finite-element models, the complete elastic properties of the trabecular architecture were obtained and maximum and mean stiffness could be calculated. Volume fraction and true three-dimensional architectural measurements of connectivity density and surface density were determined. Connectivity density was determined in an unbiased manner by the Euler number, which is a topological property. Using multiple regression analysis it was found that volume fraction explained by far the greatest part (84%-94%) of the variation in both mean and maximum stiffness. When connectivity density and surface density were included, the correlations increased marginally to 89%-95%, Noticeably negative regression coefficients were found for connectivity density. The results suggest that, in normal cancellous bone, the connectivity density has very limited value for assessment of elastic properties by morphological variables, but if a relation exists then stiffness decreases with increasing connectivity, (Bone 24:115-120; 1999) (C) 1999 by Elsevier Science Inc. All rights reserved.