Bone matrix in the solid state: geometric influence on differentiation of fibroblasts.
Bone matrix in the solid state: geometric influence on differentiation of fibroblasts.
复制标题
固态骨基质：对成纤维细胞分化的几何影响。
DOI：
10.1016/b978-0-12-005215-8.50007-3
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
A. Reddi
中科院分区：
文献类型：
--
作者：
A. Reddi
The control of gene expression of eukaryotic cells is one of the central problems of biology and medicine. It is of crucial significance in differentiation, in cancer, and in other great cellular events. The present paper is concerned with alteration of the program of fibroblasts by physiological methods. The profound influence of geometry upon gene expression of cells of the connective tissue will be demonstrated. Under normal circumstances all somatic cells of a multicellular organism—for example, a mammal-possess the same genome, hence an identical potential to synthesize every kind of molecule produced by each cell of the organism at all stages of its development. Yet only a small fraction of the genetic potential is expressed; the cells at an early stage become programmed and remain thereafter highly defined in identity. The cell's program, once acquired, is tenaciously retained.
