The rise and fall of malignant fibrous histiocytoma
The rise and fall of malignant fibrous histiocytoma
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DOI：
10.1080/019131290882150
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发表时间：
2004-09-01
影响因子：
1
通讯作者：
Antonescu, CR
中科院分区：
文献类型：
--
作者：
Erlandson, RA;Antonescu, CR
恶性纤维组织细胞瘤一词由Stout及其同事在20世纪60年代提出，包括可能来源于组织细胞的多形性软组织肉瘤，这些组织细胞能够成纤维细胞转化。这一概念在随后的20年里得到了重申，恶性纤维组织细胞瘤因此被认为是老年人最常见的软组织肿瘤。然而，最近更重要的临床病理学，超微结构和免疫组化研究表明，恶性纤维组织细胞瘤不是来自组织细胞的“兼性成纤维细胞”和许多肿瘤诊断实际上是其他肉瘤的多形性亚型。电镜和免疫组织化学研究还发现，更常见的Storiform-pleomorphic，粘液样，也许巨细胞亚型是由成纤维细胞和表型调制成纤维细胞，特别是肌成纤维细胞和histiofibroblasts的可变混合物。在这些发现的基础上，我们提出了一个新的分类上述亚型的所谓恶性纤维组织细胞瘤，其中大多数是多形性纤维肉瘤的变种。
The term malignant fibrous histiocytoma was coined by Stout and associates in the 1960s to encompass pleomorphic soft tissue sarcomas presumably derived from histiocytes that are capable of fibroblastic transformation. The concept was reaffirmed in the following 2 decades and malignant fibrous histiocytoma thus was regarded as the most common soft tissue tumor in older adults. However, recent more critical clinicopathologic, ultrastructural, and immunohistochemical studies have shown that malignant fibrous histiocytomas are not derived from histiocytic "facultative fibroblasts" and many neoplasms so diagnosed actually are pleomorphic subtypes of other sarcomas. Meticulous electron microscopic and immunohistochemical investigations also found that the more common storiform-pleomorphic, myxoid, and perhaps the giant cell subtypes are composed of variable mixtures of fibroblasts and phenotypically modulated fibroblastic cells, notably myofibroblasts and histiofibroblasts. On the basis of these findings, we propose a new classification for the above subtypes of so-called malignant fibrous histiocytoma, the majority of which are variants of pleomorphic fibrosarcoma.