Giant Intracranial Aneurysms at 7T MRI
Giant Intracranial Aneurysms at 7T MRI
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DOI：
10.3174/ajnr.a4569
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发表时间：
2016-04-01
影响因子：
3.5
通讯作者：
Wrede, K. H.
中科院分区：
文献类型：
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作者：
Matsushige, T.;Chen, B.;Wrede, K. H.
对 7 个巨大颅内动脉瘤进行了评估，其中 2 个动脉瘤可用于组织病理学检查。动脉瘤壁在 TOF-MRA 和 SWI 序列中被描绘为低信号，与邻近的脑实质具有良好的对比度。在 TOF-MRA 和 SWI 中，所有动脉瘤均可看到动脉瘤壁的三层微结构。这可能与壁中的铁沉积有关，并且在 2 个可用的组织病理学标本中也发现了类似的结果。体内 7T TOF-MRA 和 SWI 可以勾画出巨大颅内动脉瘤的动脉瘤壁和三层壁微结构。摘要：巨大颅内动脉瘤是一种罕见的血管病变，具有高发病率和死亡率。这项体内研究的目的是通过 7T MR 成像评估巨大的颅内动脉瘤及其壁微观结构，以前仅在组织病理学检查中可视化。对 7 个巨大颅内动脉瘤进行了评估，其中 2 个动脉瘤可用于组织病理学检查。 7 例中有 6 例（85.7%）显示不同大小的管腔内血栓。动脉瘤壁在 TOF-MRA 和 SWI 序列中被描绘为低信号，与相邻脑实质具有出色的对比度（范围分别为 0.01-0.60 和 0.58-0.96）。所有动脉瘤的动脉瘤壁三层微结构均在 TOF-MRA 和 SWI 中可视化。这可能与壁中的铁沉积有关，类似于 2 个可用的组织病理学标本中的发现。体内7T TOF-MRA和SWI可以勾画出颅内巨大动脉瘤的动脉瘤壁和三层壁微结构。
Seven giant intracranial aneurysms were evaluated, and 2 aneurysms were available for histopathologic examination. Aneurysm walls were depicted as hypointense in TOF-MRA and SWI sequences with excellent contrast ratios to adjacent brain parenchyma. A triple-layered microstructure of the aneurysm walls was visualized in all aneurysms in TOF-MRA and SWI. This could be related to iron deposition in the wall, and similar findings were seen in 2 available histopathologic specimens. In vivo 7T TOF-MRA and SWI can delineate the aneurysm wall and the triple-layered wall microstructure in giant intracranial aneurysms.SUMMARY: Giant intracranial aneurysms are rare vascular pathologies associated with high morbidity and mortality. The purpose of this in vivo study was to assess giant intracranial aneurysms and their wall microstructure by 7T MR imaging, previously only visualized in histopathologic examinations. Seven giant intracranial aneurysms were evaluated, and 2 aneurysms were available for histopathologic examination. Six of 7 (85.7%) showed intraluminal thrombus of various sizes. Aneurysm walls were depicted as hypointense in TOF-MRA and SWI sequences with excellent contrast ratios to adjacent brain parenchyma (range, 0.01-0.60 and 0.58-0.96, respectively). The triple-layered microstructure of the aneurysm walls was visualized in all aneurysms in TOF-MRA and SWI. This could be related to iron deposition in the wall, similar to the findings in 2 available histopathologic specimens. In vivo 7T TOF-MRA and SWI can delineate the aneurysm wall and the triple-layered wall microstructure in giant intracranial aneurysms.