Recent progress in the cellular and molecular biology of prostaglandin synthesis
Recent progress in the cellular and molecular biology of prostaglandin synthesis
复制标题
DOI：
10.1016/s1050-1738(98)00004-8
复制
发表时间：
1998-05-01
影响因子：
9.3
通讯作者：
Herschman, HR
中科院分区：
文献类型：
--
作者：
Herschman, HR
前列腺素合成酶可诱导形式的发现引发了对配体诱导前列腺素合成的生化途径的重新研究。因此，具有治疗疼痛、发热、慢性和急性炎症、心血管疾病和结肠癌的潜在活性的新的药物已经被开发出来，目前正在进行深入的研究。对前列腺素合成酶的结构性和诱导性之间的差异进行了仔细的生化和药理学研究，表明阿司匹林的一些疗效是以前意想不到的机制。对一种新的磷脂酶的鉴定，以及对其在肥大细胞前列腺素合成和跨细胞前列腺素合成中作用的认识，为炎症和其他前列腺素介导的疾病的药物干预确定了更多的潜在靶点。(C)1998年，爱思唯尔科学公司。
The discovery of an inducible form of prostaglandin synthase initiated a reexamination of the biochemical pathways for ligand-induced prostaglandin synthesis. As a result, new pharmaceutical agents with potential activity against pain, fever, chronic and acute inflammation, cardiovascular disorders, and colon cancer have been developed and are currently under intense investigation. Careful biochemical and pharmacologic studies of the differences between the constitutive and inducible prostaglandin synthase enzymes have suggested a previously unexpected mechanism for some of the therapeutic effects of aspirin. Identification of a new phospholipase, and recognition of its role in mast cell prostaglandin production and in transcellular prostaglandin synthesis, have identified additional potential targets for pharmacologic intervention in inflammation and other prostaglandin-mediated disorders. (C) 1998, Elsevier Science Inc.